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Review
. 2025 Jan 22;24(1):e12630.
doi: 10.1002/rmb2.12630. eCollection 2025 Jan-Dec.

Polycystic ovary syndrome: Criteria, phenotypes, race and ethnicity

Tsuyoshi Baba  1
Affiliations
Review

Polycystic ovary syndrome: Criteria, phenotypes, race and ethnicity

Tsuyoshi Baba. Reprod Med Biol. .

Abstract

Background: Polycystic ovary syndrome (PCOS) is a complex endocrinopathy, which leads to ovulation dysfunction and infertility, as well as metabolic and mental disorders. Women with PCOS exhibit several characteristic symptoms, with marked heterogeneity across different races and ethnicities.

Methods: In this review, the author outlines the phenotypic disparities of PCOS among various racial and ethnic populations. First, the prevalence of major symptoms in different racial and ethnic groups with PCOS is summarized. Next, the effects of four phenotypes, derived from the Rotterdam criteria for PCOS, on metabolic and reproductive features are recapitulated.

Main findings: A growing body of evidence suggests that East Asian populations exhibit less hirsutism and adiposity compared with other groups. However, hirsutism is more prevalent in South Asian, Middle Eastern, and Hispanic populations. Hispanic and African American populations have more frequent obesity and insulin resistance. With regard to the association between mental disorders and racial and ethnic differences, limited studies exist; therefore, no conclusions can be drawn.

Conclusion: Race and ethnicity-specific factors related to PCOS must be considered in clinical practice. The diagnostic criteria of PCOS should be specific to race and ethnicity to avoid missing treatment opportunities.

Keywords: diagnosis; ethnicity; phenotype; polycystic ovary syndrome; race.

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Conflict of interest statement

The author declares no conflict of interest for this article.

Figures

FIGURE 1
FIGURE 1
Putative pathogeneses of PCOS. Hypothetical etiology of excessive prenatal androgen exposure owing to genetic or prenatal environmental factors affecting various organs, which leads to programming of PCOS, such as hypothalamic dysregulation, functional ovarian hyperandrogenism, and metabolic disorders. CVD, cardiovascular disease; DM, diabetes mellitus; LH, luteinizing hormone; PCOS, polycystic ovary syndrome.
FIGURE 2
FIGURE 2
Relationships among various symptoms of PCOS. Hyperandrogenism, overweight/obesity, and insulin resistance are cardinal components of PCOS and are closely related to each other. The line thickness denotes the strength of the effect. AMH, anti‐Müllerian hormone; PCOM, polycystic ovarian morphology; PCOS, polycystic ovary syndrome.
See this image and copyright information in PMC

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