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. 2024 Nov 20;20(2):47-52.
doi: 10.46582/jsrm.2002006. eCollection 2024.

The Effect of Human Adipose Stem Cell-Conditioned Medium (hASC-CM) in Photoaged Skin

Winawati Eka Putri  1 , Meidyta Sinantryana Widyaswari  1 , Cita Rosita Sigit Prakoeswa  2 , David Sajid Muhammad  3 , Deny Febriwijaya Romadhani  3 , Nadia Nisaussholihah  3
Affiliations

The Effect of Human Adipose Stem Cell-Conditioned Medium (hASC-CM) in Photoaged Skin

Winawati Eka Putri et al. J Stem Cells Regen Med. .

Abstract

Background: Ultraviolet (UV) exposure causes direct and indirect damages to skin structures. Human adipose stem cell-conditioned medium (hASC-CM) is a collection of several soluble factors, such as cytokines, chemokines, and Growth Factors (GF), secreted by almost all living cells in the extracellular space which support wound healing and skin rejuvenation. Objective: To determine the effects of human adipose stem cell-conditioned medium (hASC-CM) in photoaged skin and evaluate photoaging improvement after treatment. Methods: An experimental randomized controlled trial was performed, involving 64 photoaged subjects at the Dermato-Venereology Outpatient Clinic of Jemursari Islamic Hospital Surabaya from March to June 2022. The subjects were divided into the hASC-CM group and vehiculum (control) group. Patients' transepidermal water loss value, skin tone, and Glogau score in weeks 0, 4, and 8 were evaluated. The data were then analyzed using Mann-Whitney test (p<0.05). Results: All subjects had Glogau scale of III (89.6%) with mean ± SD (3.121 ± 0.329). hASC-CM group showed higher improvements in the pore, wrinkle, spot polarized, spot UV parameters and skin tone compared to vehiculum group(p<0.05). Conclusions: hASC-CM effectively improved all parameters observed. The limitation of this research was on the lack of long-term follow-up after treatment. This research had received an ethical permit from The Ethical Committee Board of Jemursari Islamic Hospital Surabaya under letter 006/KEPK-RSISJS/II/2022.

Keywords: Glogau score; Photoaging; Skin analyzer; TEWL; hASC-CM.

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Conflict of interest statement

All of the authors have equally contributed.There are no potential conflicts of interest to declare by the authors.This study was funded by L’Oréal as part of the Hair and Skin Research Grant 2021 program.

Figures

Figure 1.
Figure 1.. Glogau score improvement; (A) hASC-CM week 0; (B) hASC-CM week 8;(C) Gel week 0; (D) Gel week 8
See this image and copyright information in PMC

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