Enhancing Biomedicine: Proteomics and Metabolomics in Action

doi:10.3390/proteomes13010005

Editorial

. 2025 Jan 16;13(1):5.

doi: 10.3390/proteomes13010005.

Enhancing Biomedicine: Proteomics and Metabolomics in Action

Michele Costanzo^{1

2}, Marianna Caterino^{1

2}, Lucia Santorelli³

Affiliations

¹ Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.
² CEINGE-Biotecnologie Avanzate Franco Salvatore, 80145 Naples, Italy.
³ Clinical Proteomics and Metabolomics Unit, School of Medicine and Surgery, University of Milano-Bicocca, Vedano al Lambro, 20900 Monza, Italy.

PMID: 39846636
PMCID: PMC11755564
DOI: 10.3390/proteomes13010005

Editorial

Enhancing Biomedicine: Proteomics and Metabolomics in Action

Michele Costanzo et al. Proteomes. 2025.

. 2025 Jan 16;13(1):5.

doi: 10.3390/proteomes13010005.

Authors

Michele Costanzo^{1

2}, Marianna Caterino^{1

2}, Lucia Santorelli³

Affiliations

¹ Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.
² CEINGE-Biotecnologie Avanzate Franco Salvatore, 80145 Naples, Italy.
³ Clinical Proteomics and Metabolomics Unit, School of Medicine and Surgery, University of Milano-Bicocca, Vedano al Lambro, 20900 Monza, Italy.

PMID: 39846636
PMCID: PMC11755564
DOI: 10.3390/proteomes13010005

Abstract

The rapid and substantial advancements in proteomic and metabolomic technologies have revolutionized our ability to investigate biological systems [...].

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Conflict of interest statement

The authors declare no conflicts of interest.

References

1. Gonçalves E., Poulos R.C., Cai Z., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., et al. Pan-Cancer Proteomic Map of 949 Human Cell Lines. Cancer Cell. 2022;40:835–849.e8. doi: 10.1016/j.ccell.2022.06.010. - DOI - PMC - PubMed
1. Costanzo M., Cevenini A., Kollipara L., Caterino M., Bianco S., Pirozzi F., Scerra G., D’Agostino M., Pavone L.M., Sickmann A., et al. Methylmalonic Acidemia Triggers Lysosomal-Autophagy Dysfunctions. Cell Biosci. 2024;14:63. doi: 10.1186/s13578-024-01245-1. - DOI - PMC - PubMed
1. Zhu Z., Cai J., Hou W., Xu K., Wu X., Song Y., Bai C., Mo Y.Y., Zhang Z. Microbiome and Spatially Resolved Metabolomics Analysis Reveal the Anticancer Role of Gut Akkermansia Muciniphila by Crosstalk with Intratumoral Microbiota and Reprogramming Tumoral Metabolism in Mice. Gut Microbes. 2023;15:2166700. doi: 10.1080/19490976.2023.2166700. - DOI - PMC - PubMed
1. Santorelli L., Costanzo M., Petrosino S., Santoro M., Caterino M., Ruoppolo M., Grumati P. Cross-Linking Mass Spectrometry to Capture Protein Network Dynamics of Cell Membranome. In: Islam Williams T., editor. Tissue Proteomics: Methods and Protocols. Springer; New York, NY, USA: 2025. pp. 241–258. - PubMed
1. Raimondo F., Pitto M. Prognostic Significance of Proteomics and Multi-Omics Studies in Renal Carcinoma. Expert Rev. Proteom. 2020;17:323–334. doi: 10.1080/14789450.2020.1772058. - DOI - PubMed

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[1] Gonçalves E., Poulos R.C., Cai Z., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., et al. Pan-Cancer Proteomic Map of 949 Human Cell Lines. Cancer Cell. 2022;40:835–849.e8. doi: 10.1016/j.ccell.2022.06.010. - DOI - PMC - PubMed

[2] Gonçalves E., Poulos R.C., Cai Z., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., et al. Pan-Cancer Proteomic Map of 949 Human Cell Lines. Cancer Cell. 2022;40:835–849.e8. doi: 10.1016/j.ccell.2022.06.010. - DOI - PMC - PubMed

[3] Costanzo M., Cevenini A., Kollipara L., Caterino M., Bianco S., Pirozzi F., Scerra G., D’Agostino M., Pavone L.M., Sickmann A., et al. Methylmalonic Acidemia Triggers Lysosomal-Autophagy Dysfunctions. Cell Biosci. 2024;14:63. doi: 10.1186/s13578-024-01245-1. - DOI - PMC - PubMed

[4] Costanzo M., Cevenini A., Kollipara L., Caterino M., Bianco S., Pirozzi F., Scerra G., D’Agostino M., Pavone L.M., Sickmann A., et al. Methylmalonic Acidemia Triggers Lysosomal-Autophagy Dysfunctions. Cell Biosci. 2024;14:63. doi: 10.1186/s13578-024-01245-1. - DOI - PMC - PubMed

[5] Zhu Z., Cai J., Hou W., Xu K., Wu X., Song Y., Bai C., Mo Y.Y., Zhang Z. Microbiome and Spatially Resolved Metabolomics Analysis Reveal the Anticancer Role of Gut Akkermansia Muciniphila by Crosstalk with Intratumoral Microbiota and Reprogramming Tumoral Metabolism in Mice. Gut Microbes. 2023;15:2166700. doi: 10.1080/19490976.2023.2166700. - DOI - PMC - PubMed

[6] Zhu Z., Cai J., Hou W., Xu K., Wu X., Song Y., Bai C., Mo Y.Y., Zhang Z. Microbiome and Spatially Resolved Metabolomics Analysis Reveal the Anticancer Role of Gut Akkermansia Muciniphila by Crosstalk with Intratumoral Microbiota and Reprogramming Tumoral Metabolism in Mice. Gut Microbes. 2023;15:2166700. doi: 10.1080/19490976.2023.2166700. - DOI - PMC - PubMed

[7] Santorelli L., Costanzo M., Petrosino S., Santoro M., Caterino M., Ruoppolo M., Grumati P. Cross-Linking Mass Spectrometry to Capture Protein Network Dynamics of Cell Membranome. In: Islam Williams T., editor. Tissue Proteomics: Methods and Protocols. Springer; New York, NY, USA: 2025. pp. 241–258. - PubMed

[8] Santorelli L., Costanzo M., Petrosino S., Santoro M., Caterino M., Ruoppolo M., Grumati P. Cross-Linking Mass Spectrometry to Capture Protein Network Dynamics of Cell Membranome. In: Islam Williams T., editor. Tissue Proteomics: Methods and Protocols. Springer; New York, NY, USA: 2025. pp. 241–258. - PubMed

[9] Raimondo F., Pitto M. Prognostic Significance of Proteomics and Multi-Omics Studies in Renal Carcinoma. Expert Rev. Proteom. 2020;17:323–334. doi: 10.1080/14789450.2020.1772058. - DOI - PubMed

[10] Raimondo F., Pitto M. Prognostic Significance of Proteomics and Multi-Omics Studies in Renal Carcinoma. Expert Rev. Proteom. 2020;17:323–334. doi: 10.1080/14789450.2020.1772058. - DOI - PubMed

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Enhancing Biomedicine: Proteomics and Metabolomics in Action

Affiliations

Enhancing Biomedicine: Proteomics and Metabolomics in Action

Authors

Affiliations

Abstract

Conflict of interest statement

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