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Review
. 2025 Jan 17;11(1):7.
doi: 10.3390/ncrna11010007.

The Role of Long Non-Coding RNA in the Pathogenesis of Psoriasis

Kajetan Kiełbowski  1 , Anna Jędrasiak  1 , Estera Bakinowska  1 , Andrzej Pawlik  1
Affiliations
Review

The Role of Long Non-Coding RNA in the Pathogenesis of Psoriasis

Kajetan Kiełbowski et al. Noncoding RNA. .

Abstract

Psoriasis is a chronic immune-mediated disease with complex pathogenesis. The altered proliferation and differentiation of keratinocytes, together with the activity of dendritic cells and T cells, are crucial drivers of psoriasis progression. Long non-coding RNAs (lncRNAs) are composed of over 200 nucleotides and exert a large variety of functions, including the regulation of gene expression. Under pathological conditions, the expression of lncRNAs is frequently dysregulated. Recent studies demonstrated that lncRNAs significantly affect major cellular processes, and their aberrant expression is likely involved in the pathogenesis of various disorders. In this review, we will discuss the role of lncRNAs in the pathophysiology of psoriasis. We will summarize recent studies that investigated the relationships between lncRNAs and keratinocyte proliferation and pro-inflammatory responses.

Keywords: inflammation; keratinocyte proliferation; long non-coding RNA; psoriasis.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
A simplified model of immune cells implicated in the pathogenesis of psoriasis. Dendritic cells secrete IL-23, which induces the differentiation of Th22 and Th17 cells. Cytokines secreted by differentiated T cells induce keratinocyte activation and drive the development of psoriatic lesions. Created in BioRender. Kiełbowski, K. https://BioRender.com/p62u479.
Figure 2
Figure 2
Long non-coding RNAs regulate the expression of STAT3 transcription factor to mediate keratinocyte proliferation. Created in BioRender. Kiełbowski, K. https://BioRender.com/u84r183.
Figure 3
Figure 3
The involvement of long non-coding RNA in the IL-22- and IL-17-mediated stimulation of keratinocyte proliferation. Created in BioRender. Kiełbowski, K. https://BioRender.com/v29i018.
See this image and copyright information in PMC

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