The Review of Modified Intersphincteric Resection in the Treatment of Ultra-Low Rectal Cancer
- PMID: 39847237
- PMCID: PMC11836164
- DOI: 10.1007/s11864-025-01291-y
The Review of Modified Intersphincteric Resection in the Treatment of Ultra-Low Rectal Cancer
Abstract
Colorectal cancer is the third leading cause of cancer death worldwide. In China, the incidence and mortality of colorectal cancer are increasing, in which low rectal cancer is more common. Ultra-low rectal cancer refers to rectal cancer where the distance between the tumor and the anus is less than 5 cm, it accounts for about 70%-80% of rectal tumors. Intersphincteric resection (ISR), an important technical means for anal preservation of ultra-low rectal cancer, although could reduce the pain of patients during the surgical process, increase the anal preservation rate of patients and improve the life quality of patients, still has many adverse effects such as the high incidence of anorectal anastomotic leakage and high anterior resection syndrome. Many modified ISRs have emerged due to the limitations and adverse reactions of traditional ISR surgery. the purpose of this article is to review the progress of ISR surgery to improve its use in treatment.
Keywords: Anal preservation; ISR; Intersphincteric resection; Ultra-low rectal cancer.
© 2025. The Author(s).
Conflict of interest statement
Declarations. Conflict of interest: The authors declare no competing interests. Human and animal rights and informed consent: This article does not contain any studies with human or animal subjects performed by any of the authors.
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References
-
- [Chinese Protocol of Diagnosis and Treatment of Colorectal Cancer (2023 edition)]. Zhonghua Wai Ke Za Zhi, 2023;61(8):617–644. 10.3760/cma.j.cn112139-20230603-00222 - PubMed
-
- Park JS, et al. Laparoscopic versus open intersphincteric resection and coloanal anastomosis for low rectal cancer: intermediate-term oncologic outcomes. Ann Surg. 2011;254(6):941–6. 10.1097/SLA.0b013e318236c448. - PubMed
-
- Peng B, et al. Intersphincteric Resection Versus Abdominoperineal Resection for Low Rectal Cancer: A Meta-Analysis. Surg Innov. 2020;27(4):392–401. 10.1177/1553350620918414. - PubMed
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