Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2025 Apr 23;117(4):qiaf007.
doi: 10.1093/jleuko/qiaf007.

Apolipoprotein E aggregation in microglia, seeds β-amyloidosis in Alzheimer's disease

Miguel A Jiménez-Acosta  1 , Cristina A Luckie-Duque  1 , Marco A Meraz-Ríos  1
Affiliations
Editorial

Apolipoprotein E aggregation in microglia, seeds β-amyloidosis in Alzheimer's disease

Miguel A Jiménez-Acosta et al. J Leukoc Biol. .

Abstract

The seeded proliferation of harmful protein aggregates is fundamental to the pathophysiology of Alzheimer's disease (AD), although the initiation of this pathological cascade remains incompletely elucidated. Kaji et al. have developed a transgenic knockin mouse that expresses HaloTag-tagged APOE and discovered fibrillary aggregates of APOE in animals exhibiting amyloid-β (Aβ) amyloidosis. The APOE aggregates that tested positive for β-sheet-binding dyes induced Aβ amyloidosis in the endo-lysosomal system of microglia, a process modulated by microglial lipid metabolism and the JAK/STAT signaling pathway, indicating that the endocytic uptake and aggregation of APOE by microglia can initiate Aβ-plaque formation.

Keywords: APOE; Alzheimer’s disease; microglia; β-amyloid.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest statement. None declared.

Publication types