Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2025 Mar;211(3):307-309.
doi: 10.1164/rccm.202411-2331ED.

Decoding Sepsis Globally: Toward Precision Medicine through Clustering in Sub-Saharan Africa

Affiliations
Editorial

Decoding Sepsis Globally: Toward Precision Medicine through Clustering in Sub-Saharan Africa

Aleksandra Leligdowicz et al. Am J Respir Crit Care Med. 2025 Mar.
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Toward precision medicine through global sepsis clustering: current insights (2025) and vision for the future (2035).

Comment on

References

    1. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) JAMA . 2016;315:801–810. - PMC - PubMed
    1. Abraham E. New definitions for sepsis and septic shock: continuing evolution but with much still to be done. JAMA . 2016;315:757–759. - PubMed
    1. Leligdowicz A, Harhay MO, Calfee CS. Immune modulation in sepsis, ARDS, and Covid-19—the road traveled and the road ahead. NEJM Evid . 2022;1:EVIDra2200118. - PubMed
    1. Maslove DM, Tang B, Shankar-Hari M, Lawler PR, Angus DC, Baillie JK, et al. Redefining critical illness. Nat Med . 2022;28:1141–1148. - PubMed
    1. Sinha P, Delucchi KL, McAuley DF, O’Kane CM, Matthay MA, Calfee CS. Development and validation of parsimonious algorithms to classify acute respiratory distress syndrome phenotypes: a secondary analysis of randomised controlled trials. Lancet Respir Med . 2020;8:247–257. - PMC - PubMed

LinkOut - more resources