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Review
. 2025 Jan 9:15:1444940.
doi: 10.3389/fendo.2024.1444940. eCollection 2024.

Extracellular vesicular microRNAs and cardiac hypertrophy

Hai Hu  1   2 , Xiulian Wang  1 , Hui Yu  1   2 , Zhanli Wang  1
Affiliations
Review

Extracellular vesicular microRNAs and cardiac hypertrophy

Hai Hu et al. Front Endocrinol (Lausanne). .

Abstract

Cardiac hypertrophy is an adaptive response to pressure or volume overload such as hypertension and ischemic heart diseases. Sustained cardiac hypertrophy eventually leads to heart failure. The pathophysiological alterations of hypertrophy are complex, involving both cellular and molecular systems. Understanding the molecular events that inhibit or repress cardiac hypertrophy may help identify novel therapeutic strategies. Increasing evidence has indicated that extracellular vesicle (EV)-derived microRNAs (miRNAs) play a significant role in the development and progression of cardiac hypertrophy. In this review, we briefly review recent advancements in EV research, especially on biogenesis, cargoes and its role in cardiac hypertrophy. We then describe the latest findings regarding EV-derived miRNAs, highlighting their functions and regulatory mechanisms in cardiac hypertrophy. Finally, the potential role of EV-derived miRNAs as targets in the diagnosis and treatment of cardiac hypertrophy will be discussed.

Keywords: cardiac hypertrophy; extracellular vesicle; inflammation; microRNA; regulatory mechanism.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Role of EV-derived miRNAs in cardiac hypertrophy. Different EV-derived miRNAs cause cardiac hypertrophy through different mechanisms and even multiple mechanisms.
See this image and copyright information in PMC

References

    1. van Berlo JH, Maillet M, Molkentin JD. Signaling effectors underlying pathologic growth and remodeling of the heart. J Clin Invest. (2013) 123:37–45. doi: 10.1172/JCI62839 - DOI - PMC - PubMed
    1. Vega RB, Konhilas JP, Kelly DP, Leinwand LA. Molecular mechanisms underlying cardiac adaptation to exercise. Cell Metab. (2017) 25:1012–26. doi: 10.1016/j.cmet.2017.04.025 - DOI - PMC - PubMed
    1. Nakamura M, Sadoshima J. Mechanisms of physiological and pathological cardiac hypertrophy. Nat Rev Cardiol. (2018) 15:387–407. doi: 10.1038/s41569-018-0007-y - DOI - PubMed
    1. Waldenström A, Ronquist G. Role of exosomes in myocardial remodeling. Circ Res. (2014) 114:315–24. doi: 10.1161/CIRCRESAHA.114.300584 - DOI - PubMed
    1. Zhang P, Su J, Mende U. Cross talk between cardiac myocytes and fibroblasts: from multiscale investigative approaches to mechanisms and functional consequences. Am J Physiol Heart Circ Physiol. (2012) 303:H1385–96. doi: 10.1152/ajpheart.01167.2011 - DOI - PMC - PubMed

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