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. 2024 Dec 30;13(1):23.
doi: 10.3390/vaccines13010023.

Optimizing Varicella Vaccination Strategy: A Study on Age and Dose Impacts on Antibody Levels

Qing He  1   2 , Yang Xu  1   2 , Yilan Li  1   2 , Pinting Zhu  1   2 , Lei Luo  1   2
Affiliations

Optimizing Varicella Vaccination Strategy: A Study on Age and Dose Impacts on Antibody Levels

Qing He et al. Vaccines (Basel). .

Abstract

Seropositivity study of Varicella in Healthy Populations in Guangzhou, China. Infection with varicella-zoster virus (VZV) leads to skin and mucous membranes blisters and the complications can be life threatening. A seroepidemiological study conducted from 2020 to 2022 in Guangzhou, China, aimed to evaluate varicella antibody levels. We measured varicella antibody concentrations using an enzyme-linked immunosorbent assay. A total of 3300 people were enrolled in the study. The mean varicella antibody level was 171.2 mIU/mL (95% CI: 158.9, 184.4), with an overall positivity rate of 67.00% (95% CI: 65.37, 68.60). The mean level of those positive subjective was 581.2 mIU/mL (95% CI: 552.3, 611.5). Varicella antibody levels were found to be influenced by age, vaccination dosage, and history of varicella infection. Antibody level increased with age and the number of vaccinations. The antibody induced by the varicella vaccine remained at protective levels for at least 6 years post-vaccination. We recommend two doses of the varicella vaccine for both children and adults and the integration of the varicella vaccine into the national routine immunization program.

Keywords: seroepidemiology; vaccination; varicella.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Positive rate and Geometric mean concentrations of varicella antibody for different vaccination status among subjects aged 0–18 years.
Figure 2
Figure 2
Positive rate and Geometric mean concentrations of varicella antibody for 1 or 2 doses among groups of time since vaccination.
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