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. 2025 Jan 24.
doi: 10.1007/s00428-025-04032-6. Online ahead of print.

Trichogerminoma with malignant transformation

Thibault Kervarrec  1   2   3 , Maxence Mancini  4 , Anne Tallet  5 , Samia Mourah  4 , Maxime Battistella #  6   7 , Eric Frouin #  6   8
Affiliations

Trichogerminoma with malignant transformation

Thibault Kervarrec et al. Virchows Arch. .

Abstract

Trichogerminoma (TG) is a rare adnexal tumor with hair follicle differentiation with less than 50 cases reported in the literature. In 2022, by investigating the genetic profile of 21 cases, our group identified recurrent rearrangements of the GRHL1/2/3 genes in this tumor entity, suggesting such alteration as the main oncogenic driver in TG. Up to now, only one TG case of malignant transformation has been reported. In the present letter, we report a second case of TG with malignant transformation and provide molecular characterization of this tumor.

Keywords: GRHL1/2/3 genes; Adnexal tumors; Carcinoma; Malignant; Trichogerminoma.

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Conflict of interest statement

Declarations. Ethical approval: Local Ethics Committee in Human Research, Tours, France; No. ID RCB2009-A01056-51. Conflict of interest: The authors declare no competing interests.

References

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