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Review
. 2025 Apr;155(4):1124-1132.
doi: 10.1016/j.jaci.2025.01.013. Epub 2025 Jan 22.

Update on atopic dermatitis

Shannon Meledathu  1 , Malini P Naidu  1 , Patrick M Brunner  2
Affiliations
Free article
Review

Update on atopic dermatitis

Shannon Meledathu et al. J Allergy Clin Immunol. 2025 Apr.
Free article

Abstract

Atopic dermatitis is the most common chronic inflammatory skin condition. This review highlights most recent advances in understanding and treating this debilitating disease. We summarize new insights regarding molecular endotypes and clinical phenotypes that characterize atopic dermatitis, the role of the skin microbiome, and improvements in diagnostic tools. We also emphasize recent scientific advancements in understanding the mechanisms driving atopic dermatitis pathogenesis and discuss the identification and implementation of new targeted treatment approaches that have revolutionized therapeutic options for affected patients.

Keywords: Atopic dermatitis.

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Conflict of interest statement

Disclosure statement Funded by a research grant to P.M.B. from the LEO Foundation (grant LF-OC-23-001313). Disclosure of potential conflict of interest: P. M. Brunner has received personal fees from Almirall, Sanofi, Janssen, Amgen, LEO Pharma, AbbVie, Pfizer, Boehringer Ingelheim, GSK, Regeneron, Eli Lilly, Celgene, Arena Pharma, Novartis, UCB Pharma, Biotest, and BMS; has received research support from Pfizer (grant paid to his institution); and is investigator for Pfizer and AbbVie. The rest of the authors declare that they have no relevant conflicts of interest.

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