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Comment
. 2025 Jan 24;29(1):44.
doi: 10.1186/s13054-025-05267-0.

Pulmonary pathology in culture-negative sepsis: a potential confounder for sepsis treatment and research

Brett Biebelberg  1   2
Affiliations
Comment

Pulmonary pathology in culture-negative sepsis: a potential confounder for sepsis treatment and research

Brett Biebelberg. Crit Care. .
No abstract available

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. Author information: BB is a sepsis researcher and has previously published on related topics including the heterogeneity of sepsis and differences in sepsis with or without positive cultures

Comment on

References

    1. Chang Y, Oh JH, Oh DK, et al. Culture-negative sepsis may be a different entity from culture-positive sepsis: a prospective nationwide multicenter cohort study. Crit Care. 2024;28:385. 10.1186/s13054-024-05151-3. - PMC - PubMed
    1. Biebelberg B, Rhee C, Chen T, McKenna C, Klompas M. Heterogeneity of sepsis presentations and mortality rates. Ann Intern Med. 2024;177(7):985–7. 10.7326/M24-0400. - PubMed
    1. Chalasani NP, Valdecanas MA, Gopal AK, McGowan JE Jr, Jurado RL. Clinical utility of blood cultures in adult patients with community-acquired pneumonia without defined underlying risks. Chest. 1995;108(4):932–6. 10.1378/chest.108.4.932. - PubMed
    1. García-Vázquez E, Marcos MA, Mensa J, et al. Assessment of the usefulness of sputum culture for diagnosis of community-acquired pneumonia using the PORT predictive scoring system. JAMA Intern Med. 2004;164(16):1807–11. 10.1001/archinte.164.16.1807. - PubMed
    1. Biebelberg B, Filbin MR, Lynch JC, Heldt T, Reisner AT. Comparison of CMS SEP-1 sepsis patients with and without positive blood cultures. Acad Emerg Med. 2020;27(S1):S194–5.

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