doi: 10.1080/00034983.1985.11811885.
Meningo-encephalitis accompanying retinochoroiditis in a murine model of congenital toxoplasmosis
- PMID: 3985703
- DOI: 10.1080/00034983.1985.11811885
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Meningo-encephalitis accompanying retinochoroiditis in a murine model of congenital toxoplasmosis
Ann Trop Med Parasitol.
1985 Feb.
Abstract
A histopathological study of the brains of adult mice infected in utero with Toxoplasma gondii and presenting manifestations of ocular toxoplasmosis is reported. All brains contained Toxoplasma tissue cysts. A sub-acute/chronic meningo-encephalitis was the main feature of the inflammatory response in the brain. Microscopical features suggest that autoimmune processes may play a part in the disease. We suggest that our mouse model will provide a simple and inexpensive tool for the investigation of histopathological processes in the CNS resulting from congenital Toxoplasma infection.
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