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. 2024 Dec 28;15(1):21.
doi: 10.3390/life15010021.

Sarcopenia as a Predictor of Mortality in a Cohort of Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography

Giacomo Mulinacci  1 , Clara Benedetta Conti  1 , Alberto Savino  2 , Davide Gandola  3 , Davide Ippolito  3 , Roberto Frego  1 , Alessandro Ettore Redaelli  1 , Marta Maino  1 , Marco Emilio Dinelli  1
Affiliations

Sarcopenia as a Predictor of Mortality in a Cohort of Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography

Giacomo Mulinacci et al. Life (Basel). .

Abstract

Background and aims: Despite technical advances, endoscopic retrograde cholangiopancreatography (ERCP) is associated with complications and potentially lethal outcomes. Sarcopenia, a complex syndrome mainly associated with aging, has been recognized as a predictor of poor surgical outcomes. Thus far, the impact of sarcopenia on ERCP remains unknown. The present study evaluates the role of sarcopenia as a predictor of ERCP-related outcomes in a cohort of elderly patients.

Methods: Patients who underwent ERCP between June 2019 and January 2023 were retrospectively included. Demographic and procedure-associated data were collected. Sarcopenia was assessed using the skeletal muscle index (SMI) measured from a single axial slice through the L3 vertebra on a CT scan. ERCP-related outcomes were recorded. Univariate and multivariate analyses were used to assess the correlation between sarcopenia and procedural outcomes.

Results: In total, 256 patients were enrolled, of whom 30 (11.7%) were sarcopenic. Cardiopulmonary complications of ERCP occurred in 3.5%. Sarcopenia was associated with higher 30-day and 12-month post-ERCP mortality (OR 3.45, p = 0.03; OR 3.87, p = 0.004) and longer hospitalization time (7 vs. 11 days, p = 0.003).

Conclusions: SMI is an easy and objective index of sarcopenia that could be used to predict ERCP outcomes. Indeed, sarcopenia was independently associated with prolonged hospitalization and increased mortality in a retrospective cohort of elderly patients.

Keywords: CT scan; ERCP; elderly; endoscopic retrograde cholangiopancreatography; hepathobiliary endoscopy; mortality; sarcopenia; skeletal muscle index.

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Conflict of interest statement

There are no financial disclosures or conflicts of interest among the authors.

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