Analysis of Body Composition and Levels of Antimicrobial Peptides in Patients with Basal Cell Carcinoma: A Preliminary Study

Abstract

Background: Excessive body fatness is the basis of many diseases, especially civilization-related ones. The aim of this study is to analyze the body composition and serum levels of selected antimicrobial peptides (AMPs) in patients with basal cell carcinoma (BCC), in comparison to healthy controls (HCs), and investigate whether any specific parameter significantly increases the risk of BCC development. Methods: The body composition and measurements of serum levels of cathelicidin and human-beta-defensin-2 were analyzed in a group of 100 subjects (50 patients with BCC and 50 HCs). Results: There were statistically significant differences between the visceral fat rating (BCC 11.7 vs. control 10.1), cathelicidin (BCC 1022.6 vs. control 428.4), defensin-2 (BCC 1.2 vs. control 0.4), age (BCC 68.7 vs. control 62.4), and the visceral fat/muscle ratio (BCC 0.24 vs. control 0.21). Conclusions: It seems that excessive fat, especially visceral fat, may pose a risk of developing skin cancer. Therefore, it should be taken into account when caring for patients and they should be made aware that losing body weight may be important not only in reducing the risk of hypertension or diabetes but also cancer diseases. There are numerous well-known risk factors for developing skin cancer, but few are modifiable. Among these modifiable factors is the patient's weight and body composition, so improvaing lifestyle is crucial in the prevention of skin cancers.

Keywords: basal cell carcinoma; body composition; cathelicidin; defensin; skin; visceral fat.