Strategies for Early Keratoconus Diagnosis: A Narrative Review of Evaluating Affordable and Effective Detection Techniques

Abstract

Keratoconus is a progressive corneal disorder that can lead to irreversible visual impairment if not detected early. Despite its high prevalence, early diagnosis is often delayed, especially in low-to-middle-income countries due to limited awareness and restricted access to advanced diagnostic tools such as corneal topography, tomography, optical coherence tomography, and corneal biomechanical assessments. These technologies are essential for identifying early-stage keratoconus, yet their high cost limits accessibility in resource-limited settings. While cost and portability are important for accessibility, the sensitivity and specificity of diagnostic tools must be considered as primary metrics to ensure accurate and effective detection of early keratoconus. This review examines both traditional and advanced diagnostic techniques, including the use of machine learning and artificial intelligence, to enhance early diagnosis. Artificial intelligence-based approaches show significant potential for transforming keratoconus diagnosis by improving the accuracy and sensitivity of early diagnosis, especially when combined with imaging devices. Notable innovations include tools such as SmartKC, a smartphone-based machine-learning application, mobile corneal topography through the null-screen test, and the Smartphone-based Keratograph, providing affordable and portable solutions. Additionally, contrast sensitivity testing demonstrates potential for keratoconus detection, although a precise platform for routine clinical use has yet to be established. The review emphasizes the need for increased awareness among clinicians, particularly in underserved regions, and advocates for the development of accessible, low-cost diagnostic tools. Further research is needed to validate the effectiveness of these emerging technologies in detecting early keratoconus.

Keywords: diagnosis; early keratoconus; keratoconus.

Figure 1

Filtering steps for study inclusion in this review.