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Review
. 2024 Dec 31;14(1):22.
doi: 10.3390/pathogens14010022.

Flaviviruses-Induced Neurological Sequelae

Samantha Gabrielle Cody  1   2 , Awadalkareem Adam  1   3 , Andrei Siniavin  1 , Sam S Kang  1 , Tian Wang  1   3   4   5
Affiliations
Review

Flaviviruses-Induced Neurological Sequelae

Samantha Gabrielle Cody et al. Pathogens. .

Abstract

Flaviviruses, a group of single-stranded RNA viruses spread by mosquitoes or ticks, include several significant neurotropic viruses, such as West Nile virus (WNV), Japanese encephalitis virus (JEV), tick-borne encephalitis virus (TBEV), and Zika virus (ZIKV). These viruses can cause a range of neurological diseases during acute infection, from mild, flu-like symptoms to severe and fatal encephalitis. A total of 20-50% of patients who recovered from acute flavivirus infections experienced long-term cognitive issues. Here, we discuss these major neurotropic flaviviruses-induced clinical diseases in humans and the recent findings in animal models and provide insights into the underlying disease mechanisms.

Keywords: animal models; flavivirus; neurological sequelae; neurotropic.

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Conflict of interest statement

The authors declare no conflicts of interest.

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