Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Jan 1;18(1):41.
doi: 10.3390/ph18010041.

Sirtuins and Their Implications in the Physiopathology of Gestational Diabetes Mellitus

Katarzyna Zgutka  1 , Marta Tkacz  1 , Marta Grabowska  2 , Wioletta Mikołajek-Bedner  3 , Maciej Tarnowski  1
Affiliations
Review

Sirtuins and Their Implications in the Physiopathology of Gestational Diabetes Mellitus

Katarzyna Zgutka et al. Pharmaceuticals (Basel). .

Abstract

Gestational diabetes mellitus (GDM) imposes serious short- and long-term health problems for the mother and her child. An effective therapeutic that can reduce the incidence of GDM and improve long-term outcomes is a major research priority and is very important for public health. Unfortunately, despite numerous studies, the molecular mechanisms underlying GDM are not fully defined and require further study. Chronic low-grade inflammation, oxidative stress, and insulin resistance are central features of pregnancies complicated by GDM. There is evidence of the involvement of sirtuins, which are NAD+-dependent histone deacetylases, in energy metabolism and inflammation. Taking these facts into consideration, the role of sirtuins in the pathomechanism of GDM will be discussed.

Keywords: gestational diabetes; inflammation; pregnancy; sirtuins.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Overview and summary of pathological features, symptoms, and diagnostic strategy of gestational diabetes mellitus.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Di Cianni G., Miccoli R., Volpe L., Lencioni C., Del Prato S. Intermediate metabolism in normal pregnancy and in gestational diabetes. Diabetes Metab. Res. Rev. 2003;19:259–270. doi: 10.1002/dmrr.390. - DOI - PubMed
    1. Butte N.F. Carbohydrate and lipid metabolism in pregnancy: Normal compared with gestational diabetes mellitus. Am. J. Clin. Nutr. 2000;71:1256S–1261S. doi: 10.1093/ajcn/71.5.1256s. - DOI - PubMed
    1. Hedderson M.M., Gunderson E.P., Ferrara A. Gestational weight gain and risk of gestational diabetes mellitus. Obstet. Gynecol. 2010;115:597–604. doi: 10.1097/AOG.0b013e3181cfce4f. - DOI - PMC - PubMed
    1. Santangelo C., Zicari A., Mandosi E., Scazzocchio B., Mari E., Morano S., Masella R. Could gestational diabetes mellitus be managed through dietary bioactive compounds? Current knowledge and future perspectives. Br. J. Nutr. 2016;115:1129–1144. doi: 10.1017/S0007114516000222. - DOI - PMC - PubMed
    1. Amiri F.N., Faramarzi M., Bakhtiari A., Omidvar S. Risk Factors for Gestational Diabetes Mellitus: A Case-Control Study. Am. J. Lifestyle Med. 2018;15:184–190. doi: 10.1177/1559827618791980. - DOI - PMC - PubMed

LinkOut - more resources