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. 2025 Jan 10;17(2):242.
doi: 10.3390/nu17020242.

Vitamin Metabolism and Its Dependency on Genetic Variations Among Healthy Adults: A Systematic Review for Precision Nutrition Strategies

Elana Sophie Bösch  1   2 , Jörg Spörri  1   2 , Johannes Scherr  1   2
Affiliations

Vitamin Metabolism and Its Dependency on Genetic Variations Among Healthy Adults: A Systematic Review for Precision Nutrition Strategies

Elana Sophie Bösch et al. Nutrients. .

Abstract

Background/objectives: In recent years, there has been a growing interest in precision nutrition and its potential for disease prevention. Differences in individual responses to diet, especially among populations of different ancestry, have underlined the importance of understanding the effects of genetic variations on nutrient intake (nutrigenomics). Since humans generally cannot synthesize essential vitamins, the maintenance of healthy bodily functions depends on dietary vitamin intake. Understanding the differences in vitamin uptake and metabolism across diverse populations may allow for targeted treatment plans and improved overall health. We assessed the current scientific evidence on genetic variations (such as single-nucleotide polymorphisms (SNPs)) affecting vitamin metabolism in humans.

Methods: A systematic literature review of primary studies on genetic variations associated with (personalized) nutrition was conducted. Using key terms related to personalized nutrition, nutrigenomics, SNPs, and genetic variations, three online databases were searched for studies published between 2007 and 2023 that included healthy adult subjects. Only results that were confirmed at least once were included. Study quality was assessed with the Joanna Briggs Institute (JBI) critical appraisal tool.

Results: Eighty-six articles were included in this review. Our analysis revealed associations with homocysteine metabolism and B Vitamins, Vitamin D, and components of Vitamin E. Genetic associations with Vitamin D, particularly with the GC gene, were extensively researched and linked to lower 25(OH)D concentrations, with sunlight exposure as a contributing factor. Most variants had a negative effect on homocysteine levels. Additionally, we observed general increases in carotenoid levels in the presence of SNPs, although more research on Selenium and Selenoprotein P concentrations is warranted. No studies on Vitamin C were obtained, indicating an area for further methodological improvement. Ancestry is believed to be a significant factor influencing SNP associations and significance.

Conclusions: The current review emphasizes the importance of genetics in targeted disease prevention and health care. Our comprehensive findings may provide healthcare practitioners with reliable information to make recommendations in precision nutrition, specifically vitamin supplementation.

Keywords: B vitamins; SNPs; antioxidants; genetic variations; homocysteine; personalized nutrition; vitamin D; vitamin metabolism.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have influenced the work reported in this paper.

Figures

Figure 1
Figure 1
Preferred Reporting Items for Systematic reviews and Meta-analyses (PRISMA) 2020 flow diagram for study selection.
Figure 2
Figure 2
Homocysteine metabolism. Created with BioRender.com.
See this image and copyright information in PMC

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