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. 2025 Jan 26;90(2):21.
doi: 10.1007/s00285-025-02185-1.

A branching model for intergenerational telomere length dynamics

Athanasios Benetos  1   2 , Olivier Coudray  3 , Anne Gégout-Petit  3 , Lionel Lenôtre  4   5   6 , Simon Toupance  1 , Denis Villemonais  7   8
Affiliations

A branching model for intergenerational telomere length dynamics

Athanasios Benetos et al. J Math Biol. .

Abstract

We build and study an individual based model of the telomere length's evolution in a population across multiple generations. This model is a continuous time typed branching process, where the type of an individual includes its gamete mean telomere length and its age. We study its Malthusian's behaviour and provide numerical simulations to understand the influence of biologically relevant parameters.

Keywords: Aged structured model; Branching processes; Population dynamics; Quasi-stationary distributions; Telomeres dynamics.

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Conflict of interest statement

Declarations. Conflict of interest: The authors have no relevant financial or non-financial interests to disclose.

References

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