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. 2025 Mar 1;30(2):e240-e246.
doi: 10.4317/medoral.26886.

Vascular endothelial growth factor immunoexpression in oral paracoccidioidomycosis

E-S Dias  1 , L-C Freitas, M Miyazawa, D-A Nogueira, C-E Oliveira, A-A Pereira, J-A Hanemann
Affiliations

Vascular endothelial growth factor immunoexpression in oral paracoccidioidomycosis

E-S Dias et al. Med Oral Patol Oral Cir Bucal. .

Abstract

Background: Paracoccidioidomycosis (PCM) is a systemic mycosis endemic and limited to Latin America. Brazil is responsible for more than 80% of diagnosed cases in the world. Since PCM is not a notifiable disease, there are still no accurate data on its incidence in Brazil. Vascular endothelial growth factor (VEGF) is considered the main vascular endothelial growth factor expressed in the process of angiogenesis, both under physiological and pathological conditions. To date, there are not studies in the literature that evaluated the expression of VEGF in oral PCM lesions. Therefore, the objective of this study was to evaluate the prevalence of oral lesions of PCM diagnosed from 1998 to 2020; to analyze the immunoexpression of VEGF in oral lesions of PCM; and to compare the VEGF immunostaining with the clinical and microscopic aspects of these lesions.

Material and methods: Clinical data of 98 cases of patients with oral PCM were evaluated. A total of 41 selected cases were quantitatively and qualitatively analysed by immunohistochemistry for VEGF.

Results: Our results showed that oral PCM preferentially affects white males, with mean age of 50.2 years, and the gingiva and the alveolar ridge. It was not possible to correlate VEGF immunoexpression with clinical and microscopic variables.

Conclusions: Oral PCM is a relatively uncommon pathological condition and that, in our sample, the immunoexpression of VEGF was mild and observed in a reduced number of cases.

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Conflict of interest statement

The authors have no relevant financial or non-financial interests to disclose.

Figures

Figure 1
Figure 1
Moriform stomatitis in gingiva/alveolar ridge (A), palate (B-C), and buccal mucosa (D).
Figure 2
Figure 2
Paracoccidioides brasiliensis fungi (arrows) were present in the areas of microabscesses (A), and inside the IGMCs (B). Macrophage-compatible VEGF-immunostained cells (C). Absence of VEGF immunostaining in fungi (arrow) located inside Langhans-type IGMCs (D).
See this image and copyright information in PMC

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