Development of a comprehensive food glycomic database and its application: Associations between dietary carbohydrates and insulin resistance
- PMID: 39864179
- DOI: 10.1016/j.foodchem.2025.142977
Development of a comprehensive food glycomic database and its application: Associations between dietary carbohydrates and insulin resistance
Erratum in
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Corrigendum to "Development of a comprehensive food glycomic database and its application: Associations between dietary carbohydrates and insulin resistance" [Food Chemistry 473 (2025) 142977].Food Chem. 2025 Jul 15;480:144046. doi: 10.1016/j.foodchem.2025.144046. Epub 2025 Apr 2. Food Chem. 2025. PMID: 40180883 No abstract available.
Abstract
Carbohydrates are an integral part of a healthy diet. The molecular compositions of carbohydrates encompass a very broad range of unique structures with many being ill-defined. This vast structural complexity is distilled into vague categories such as total carbohydrates, sugars, starches, and soluble/insoluble fibers. Structural elucidation of the food glycome is until recently extremely slow and immensely challenging. Dietary carbohydrates, including monosaccharides, oligosaccharides, glycosidic linkages, and polysaccharides were determined for the most consumed foods in the US consisting of 250 common foods using a multiglycomic platform. The food glycome was then correlated with clinical data from the National Health and Nutrition Examination Survey (NHANES) consisting of dietary recalls from 13,550 adults to determine associations between dietary carbohydrates, their structural features and insulin resistance. Several features were more powerful predictors compared to traditional measures indicating the need for molecular fine-scale food carbohydrate data in guiding precision nutrition initiatives and clinical studies.
Copyright © 2024. Published by Elsevier Ltd.
Conflict of interest statement
Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Carlito B. Lebrilla reports financial support was provided by National Institutes of Health. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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