Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Jul;168(1):131-135.
doi: 10.1016/j.chest.2025.01.016. Epub 2025 Jan 24.

Use of High-Dose Hydroxocobalamin for Septic Shock

Jason R Carr  1 , Brian Locke  2 , Jayshil J Patel  3 , Ithan D Peltan  2 , Samuel M Brown  2 , Nicholas A Bosch  4 , Anica C Law  4
Affiliations

Use of High-Dose Hydroxocobalamin for Septic Shock

Jason R Carr et al. Chest. 2025 Jul.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Financial/Nonfinancial Disclosures The authors have reported to CHEST the following: I. D. P. receives funding from NIH and CDC and payments to his institution from Regeneron, Bluejay Diagnostics, and Novartis. None declared (J. R. C., B. L., J. J. P., S. M. B., N. A. B., A. C. L.).

References

    1. Evans L., Rhodes A., Alhazzani W., et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Crit Care Med. 2021;49(11):e1063–e1143. - PubMed
    1. Patel J.J., Venegas-Borsellino C., Willoughby R., Freed J.K. High-dose vitamin B12 in vasodilatory shock: a narrative review. Nutr Clin Pract. 2019;34(4):514–520. - PubMed
    1. Sacco A.J., Cunningham C.A., Kosiorek H.E., Sen A. Hydroxocobalamin in refractory septic shock: a retrospective case series. Crit Care Explor. 2021;3(4) - PMC - PubMed
    1. Brokmeier H.M., Seelhammer T.G., Nei S.D., Gerberi D.J., Mara K.C., Wittwer E.D., Wieruszewski P.M. Hydroxocobalamin for vasodilatory hypotension in shock: a systematic review with meta-analysis for comparison to methylene blue. J Cardiothorac Vasc Anesth. 2023;37(9):1757–1772. - PubMed
    1. Patel J.J., Willoughby R., Peterson J., et al. High-dose IV hydroxocobalamin (vitamin B12) in septic shock: a double-blind, allocation-concealed, placebo-controlled single-center pilot randomized controlled trial (the Intravenous Hydroxocobalamin in Septic Shock Trial) Chest. 2023;163(2):303–312. - PubMed