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Review
. 2025 Mar:206:106812.
doi: 10.1016/j.nbd.2025.106812. Epub 2025 Jan 24.

Unveiling the significance of AKAP79/150 in the nervous system disorders: An emerging opportunity for future therapies?

Chen-Chao Chu  1 , Ya-Hui Hu  1 , Gui-Zhou Li  1 , Jiang Chen  2 , Ning-Ning Zhang  3 , Yi-Xue Gu  4 , Shi-Yu Wu  1 , Hai-Feng Zhang  1 , Yang-Yang Xu  1 , Hong-Li Guo  5 , Xin Tian  6 , Feng Chen  7
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Free article
Review

Unveiling the significance of AKAP79/150 in the nervous system disorders: An emerging opportunity for future therapies?

Chen-Chao Chu et al. Neurobiol Dis. 2025 Mar.
Free article

Abstract

A-kinase anchoring protein 79/150 (AKAP79/150) is a crucial scaffolding protein that positions various proteins at specific synaptic sites to modulate excitatory synaptic intensity. As our understanding of AKAP79/150's biology deepens, along with its significant role in the pathophysiology of various human disorders, there is growing evidence that reveals new opportunities for therapeutic interventions. In this review, we examine the fundamental structure and primary functions of AKAP79/150, emphasizing its pathophysiological mechanisms in different nervous system disorders, particularly inflammatory pain, epilepsy, depression, and Alzheimer's disease. We also discuss its potential therapeutic implications for patients suffering from these conditions.

Keywords: AKAP79/150; Depression; Epilepsy; Inflammatory pain; Potential therapeutics; Structure and biological functions.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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