Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2025 Mar;66(2):107-109.
doi: 10.1111/ajd.14419. Epub 2025 Jan 25.

Ichthyosis Prematurity Syndrome

Grace X Li  1   2 , Kathryn Chen  3   4 , Deshan F Sebaratnam  1   2 , James P Pham  1   2   4
Affiliations
Case Reports

Ichthyosis Prematurity Syndrome

Grace X Li et al. Australas J Dermatol. 2025 Mar.
No abstract available

Keywords: FATP4; SLC27A4; ichthyosis congenita; ichthyosis prematurity syndrome; neonatal asphyxia; premature birth.

PubMed Disclaimer

Conflict of interest statement

D.F.S. has received consulting fees from Galderma, AbbVie, Pfizer, Amgen, Novartis, Janssen, Leo Pharma, Bristol Myers Squibb, Eli Lilly, iNOVA, Ego Pharmaceuticals and Sun Pharma, and received material support from Candela Medical and Heine Optotechnik. D.F.S. is an editorial board member of the Australasian Journal of Dermatology and a co‐author of this article. To minimise bias, he was excluded from all editorial decision‐making related to the acceptance of this article for publication. G.X.L., K.C. and J.P.P. have no conflicts of interest to report.

Figures

FIGURE 1
FIGURE 1
Thick, clay‐like ichthyosis affecting the (a) back; (b) lower limbs and dorsal surface of the hands; and (c) forehead, scalp and proximal limbs.
FIGURE 2
FIGURE 2
Chest X‐ray with ill‐defined multilobar opacities consistent with pulmonary oedema.
See this image and copyright information in PMC

References

    1. Klar J., Schweiger M., Zimmerman R., et al., “Mutations in the Fatty Acid Transport Protein 4 Gene Cause the Ichthyosis Prematurity Syndrome,” American Journal of Human Genetics 85, no. 2 (2009): 248–253. - PMC - PubMed
    1. Lwin S. M., Hsu C.‐K., McMillan J. R., Mellerio J. E., and McGrath J. A., “Ichthyosis Prematurity Syndrome: From Fetus to Adulthood,” JAMA Dermatology 152, no. 9 (2016): 1055–1058. - PubMed
    1. Severino‐Freire M., Bing Lecointe A. C., Bourrat E., et al., “Ichthyosis Prematurity Syndrome: Two New Cases,” Annales de Dermatologie et de Vénéréologie 145, no. 10 (2018): 603–606. - PubMed
    1. Khnykin D., Ronnevig J., Johnsson M., et al., “Ichthyosis Prematurity Syndrome: Clinical Evaluation of 17 Families With a Rare Disorder of Lipid Metabolism,” Journal of the American Academy of Dermatology 66, no. 4 (2012): 606–616. - PubMed
    1. Dereksson K., Kjartansson S., Hjartardottir H., and Arngrimsson R., “Ichthyosis Prematurity Syndrome With Separation of Fetal Membranes and Neonatal Asphyxia,” BMJ Case Reports 2012 (2012): bcr0220125823. - PMC - PubMed

Publication types

LinkOut - more resources