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Review
. 2025 Aug;72(4):1121-1134.
doi: 10.1002/bab.2713. Epub 2025 Jan 26.

Evaluation of the Role of PnuC Gene in Enhancing Nicotinamide Mononucleotide Synthesis

Giang Thi Thu Vo  1 , Khang Khoa Hoang Nguyen  1 , Beom Soo Kim  1
Affiliations
Review

Evaluation of the Role of PnuC Gene in Enhancing Nicotinamide Mononucleotide Synthesis

Giang Thi Thu Vo et al. Biotechnol Appl Biochem. 2025 Aug.

Abstract

The PnuC gene plays a crucial role in the complex processes related to the absorption and synthesis of the nicotinamide mononucleotide (NMN) precursor. NMN, a nicotinamide adenine dinucleotide (NAD+) precursor, is important for cellular energy metabolism, DNA repair, and antiaging. This study focuses on elucidating the precursor absorption mechanism and the specific function of the PnuC gene in encoding membrane transport proteins, as well as its impact on the regulation and dynamics of NMN within the cell. This understanding aims to provide insights into its potential effects on metabolic balance, illustrated through two NAD+ biosynthesis pathways based on renewable and readily available cytoplasmic resources, assessing the potential of PnuC gene expression in clarifying complex interactions within regulation mechanisms. Enhanced expression analysis of the PnuC gene has initiated discussions on its potential applications in treating aging-related diseases and dysfunctions, contributing to cellular health maintenance.

Keywords: PnuC gene; cellular metabolism; nicotinamide adenine dinucleotide; nicotinamide mononucleotide.

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