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. 2025 Feb;27(2):e17288.
doi: 10.1111/codi.17288.

Impact of hospital volume on survival in patients with locally advanced colon cancer - A Dutch population-based study

L C F de Nes  1   2 , P J Tanis  3 , R H Verhoeven  2   4 , J H W de Wilt  2 , P A J Vissers  2   4
Affiliations

Impact of hospital volume on survival in patients with locally advanced colon cancer - A Dutch population-based study

L C F de Nes et al. Colorectal Dis. 2025 Feb.

Abstract

Aim: Locally advanced colon cancer (LACC) often necessitates complex prognosis-determining treatment. This study investigated the impact of hospital volume on short- and long-term outcomes following surgery for LACC.

Method: Data involving all patients with LACC categorized as clinical T4 and/or N2, between 2015 and 2019 in the Netherlands, were extracted from the Netherlands Cancer Registry. Hospitals were stratified into low volume (1-19 LACC resections per year), medium volume (20-29 LACC resections per year) and high volume (≥30 LACC resections per year). Data were analysed using Kaplan-Meier curves, logistic regression analysis and Cox-regression models.

Results: A total of 49 298 patients were diagnosed with colon cancer, of whom 9206 (18.7%) had locally advanced disease. Of these 9206 patients, resection was performed in 8537 with a median age of 71 (interquartile range: 63-78) years. Patients were more likely to undergo laparoscopic procedures in high-volume hospitals than in low-volume hospitals (OR = 1.28, 95% CI: 1.12-1.46). No risk differences in anastomotic leakage or postoperative 90-day mortality were observed according to hospital volume. Five-year overall survival rates were comparable among high-, medium- and low-volume hospitals (58.7% vs. 58.0% vs. 60.0%, p = 0.62). Hospital volume was not associated with overall survival in multivariable analysis. Independent predictors of worse overall survival included older age, higher American Society of Anaesthesiologists score, emergency/urgent setting, anastomotic leakage, higher pTNM status, involved resection margins and no adjuvant chemotherapy.

Conclusion: Despite the complexity of surgical treatment, hospital volume was not associated with survival in LACC. Hospital volume might be an imperfect surrogate for quality assessment.

Keywords: adjuvant therapy; hospital volume; locally advanced colon cancer; neoadjuvant therapy; surgical procedures; survival.

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Conflict of interest statement

P. J. Tanis received research grants from Allergan (LifeCell) and the Dutch Cancer Society unrelated to the submitted work. R. H. Verhoeven received research grants from Roche and Bristol‐Myers Squibb unrelated to the submitted work. J. H. W. de Wilt reports research grants from ZonMW, the Dutch Cancer Society, Medtronic and Roche unrelated to the submitted work. The other authors have no conflicts of interest or financial ties to disclose.

Figures

FIGURE 1
FIGURE 1
Overall survival of patients with locally advanced colon cancer (LACC) who underwent resection. Survival was stratified according to hospital volume (1–19, 20–29 or ≥30 resections per year). Log rank p = 0.62.
FIGURE 2
FIGURE 2
(A) Overall survival for patients with stage cT2‐3N2 (not classified as cT4) locally advanced colon cancer (LACC) who underwent resection. Survival was stratified according to hospital volume (1–19, 20–29 or ≥30 resections per year). Log Rank p = 0.60. (B) Overall survival in patients with only cT4 stage LACC who underwent resection. Survival was stratified according to hospital volume (1–19, 20–29 or ≥30 resections per year). Log rank p = 0.60.
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