Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2024 Nov 6:9:33.
doi: 10.21037/acr-24-23. eCollection 2025.

Importance of the multidisciplinary approach in the surgical treatment of giant mediastinal neoplasms: a case series

Giovanni Tacchi  1 , Luca Frasca  1   2 , Filippo Longo  1 , Pierfilippo Crucitti  1
Affiliations
Case Reports

Importance of the multidisciplinary approach in the surgical treatment of giant mediastinal neoplasms: a case series

Giovanni Tacchi et al. AME Case Rep. .

Abstract

Background: Many reports described the importance of multidisciplinary meetings in providing oncologic patients with the best treatment strategies. This item improved overall survival, accuracy of staging and adherence to guidelines. For mediastinal neoplasms, collaboration between different surgical skills allows to deal with challenging/impossible surgical procedures. We report a series of four patients with a mediastinal-localized tumor with extensive infiltration of adjacent major structures. All cases were discussed at our multidisciplinary meeting where surgical indication was assessed. The presence of several surgical specialists, the role of anesthesiologists and sub-intensive clinicians was essential for proper operative and postoperative planning.

Case description: A 70-year-old patient with type-A thymoma underwent a via sternotomy thymectomy with an end-to-end caval anastomosis and an end-to-side anastomosis with the left brachiocephalic trunk by prosthesis. A 52-year-old patient with malignant peripheral nerve sheath tumor of left sternocleidomastoid muscle underwent surgical excision and chest wall reconstruction by Teflon prosthesis and pedicled flap from the rectus abdominis. A 41-year-old woman diagnosed with monophasic synovial sarcoma of the anterior mediastinum. After chemotherapy without benefit, she underwent debulking surgery with excision of this huge mass and right phrenic nerve reconstruction by neural graft from the contralateral phrenic nerve. A 23-year-old woman affected by myasthenia gravis (MG) with a type-B3 thymoma diagnosis. After chemotherapy without benefit, she underwent a thymectomy and left pneumectomy with reconstruction of the superior vena cava (SVC).

Conclusions: Multidisciplinary evaluation and surgical team are crucial in such complex cases to customize the most appropriate surgical planning and treatment.

Keywords: Thoracic surgery; case series; mediastinal tumor; multidisciplinary team (MDT).

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://acr.amegroups.com/article/view/10.21037/acr-24-23/coif). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Case #1 pre-surgical computed tomography scan.
Figure 2
Figure 2
Case #2 pre-surgical computed tomography scan.
Figure 3
Figure 3
Case #3 pre-surgical computed tomography scan.
Figure 4
Figure 4
Case #3 post-surgical computed tomography scan.
Figure 5
Figure 5
Case #4 pre-surgical computed tomography scan.
Figure 6
Figure 6
Case #4 post-surgical computed tomography scan.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Specchia ML, Frisicale EM, Carini E, et al. The impact of tumor board on cancer care: evidence from an umbrella review. BMC Health Serv Res 2020;20:73. 10.1186/s12913-020-4930-3 - DOI - PMC - PubMed
    1. Petrella F, Radice D, Guarize J, et al. The Impact of Multidisciplinary Team Meetings on Patient Management in Oncologic Thoracic Surgery: A Single-Center Experience. Cancers (Basel) 2021;13:228. 10.3390/cancers13020228 - DOI - PMC - PubMed
    1. Stone E, Rankin N, Kerr S, et al. Does presentation at multidisciplinary team meetings improve lung cancer survival? Findings from a consecutive cohort study. Lung Cancer 2018;124:199-204. 10.1016/j.lungcan.2018.07.032 - DOI - PubMed
    1. Smeltzer MP, Rugless FE, Jackson BM, et al. Pragmatic trial of a multidisciplinary lung cancer care model in a community healthcare setting: study design, implementation evaluation, and baseline clinical results. Transl Lung Cancer Res 2018;7:88-102. 10.21037/tlcr.2018.01.02 - DOI - PMC - PubMed
    1. Lamprell K, Arnolda G, Delaney GP, et al. The challenge of putting principles into practice: Resource tensions and real-world constraints in multidisciplinary oncology team meetings. Asia Pac J Clin Oncol 2019;15:199-207. 10.1111/ajco.13166 - DOI - PubMed

Publication types

LinkOut - more resources