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. 2024 Dec 18;6(1):e1054.
doi: 10.1002/jha2.1054. eCollection 2025 Feb.

Association of the nutritional risk index recorded prior to allogeneic hematopoietic cell transplantation with the clinical prognosis in children

Hitomi Yonesu  1 , Satoru Hamada  2 , Hideki Sakiyama  2 , Shinobu Kiyuna  2 , Tokiko Oshiro  2 , Nobuyuki Hyakuna  3 , Koichi Nakanishi  2   4
Affiliations

Association of the nutritional risk index recorded prior to allogeneic hematopoietic cell transplantation with the clinical prognosis in children

Hitomi Yonesu et al. EJHaem. .

Abstract

Introduction: The nutritional risk index (NRI), calculated using serum albumin levels and body weight ratio is a known prognostic factor in adult hematopoietic cell transplantation (HCT). However, its usefulness in pediatric HCT settings remains unclear.

Methods: In a retrospective study, we examined pre-transplant NRI impact on outcomes in 82 pediatric patients undergoing allogeneic HCT.

Results: The 2-year non-relapse mortality (NRM) rate was 7.94% (95% confidence interval [CI], 3.05%-19.8%) and 30.8% (95% CI, 16.7%-52.2%) in the high and low NRI groups, respectively (p = 0.0037).

Conclusion: We found that poor nutritional status prior to pediatric HCT led to a worse prognosis, including increased NRM.

Keywords: pediatrics; prognostic factor; stem cell transplantation.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

FIGURE 1
FIGURE 1
Two‐year probability of overall survival (OS) (A), cumulative incidence of non‐relapse mortality (NRM) (B), and cumulative incidences of relapse (C).
FIGURE 2
FIGURE 2
Cumulative incidences of grades II–IV aGVHD (A), cumulative incidences of grades III–IV aGVHD, cumulative incidences of cGVHD (C), and cumulative incidences of severe cGVHD.
See this image and copyright information in PMC

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