Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Jan 6;15(1):1-4.
doi: 10.55729/2000-9666.1445. eCollection 2025.

Gene Editing: Developments, Ethical Considerations, and Future Directions

Manav C Parikh  1
Affiliations

Gene Editing: Developments, Ethical Considerations, and Future Directions

Manav C Parikh. J Community Hosp Intern Med Perspect. .

Abstract

An examination of recent developments related to CRISPR technology, ethical considerations of the application of such technologies, and future directions for germline editing.

Keywords: Bioethics; Biotechnology; Genome/genomics; Germline editing; He Jiankui; Oversight; Regulation; Somatic cell editing.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: The author declares that he has no competing interests.

Figures

Fig. 1
Fig. 1
Timeline of developments in human germline editing.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Bak RO, Gomez-Ospina N, Porteus MH. Gene editing on center stage. Trends Genet. 2018;34(8):600–611. doi: 10.1016/j.tig.2018.05.004. - DOI - PubMed
    1. Mulvihill JJ, Capps B, Joly Y, Lysaght T, Zwart HAE, Chadwick R. Ethical issues of CRISPR technology and gene editing through the lens of solidarity. Br Med Bull. 2017;122(1):17–29. doi: 10.1093/bmb/ldx002. - DOI - PubMed
    1. Shanks Pete. European convention continues to ban germline editing. Biopolitical Times.
    1. Human Genome Editing Initiative. National academies of sciences, engineering, and medicine. [Accessed October 4, 2024]. https://www.nationalacademies.org/our-work/human-gene-editing-initiative... .
    1. He S. The first human trial of CRISPR-based cell therapy clears safety concerns as new treatment for late-stage lung cancer. Signal Transduct Targeted Ther. 2020;5(1):1–2. doi: 10.1038/s41392-020-00283-8. - DOI - PMC - PubMed

LinkOut - more resources