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. 2024 Dec;66(12):1154-1158.
doi: 10.4103/indianjpsychiatry.indianjpsychiatry_161_24. Epub 2024 Dec 12.

Cortical hypometabolism as a predictor of intermittent theta burst stimulation response in treatment-resistant depression patients: An open-label study

Nidhisha Bajaj  1 , Nand Kumar  1 , Rakesh Kumar  2 , Vaibhav Patil  1 , Anshul Sharma  3
Affiliations

Cortical hypometabolism as a predictor of intermittent theta burst stimulation response in treatment-resistant depression patients: An open-label study

Nidhisha Bajaj et al. Indian J Psychiatry. 2024 Dec.

Abstract

Background: Intermittent theta burst stimulation (iTBS) is an accepted and approved brain stimulation technique to treat patients with treatment-resistant depression.

Aim: Using neuroimaging, this open-label study aimed to predict the response by observing glucose metabolism with the help of 18-FDG PET scan.

Methods: A total of 25 treatment-resistant depression patients received 15 sessions of iTBS on the left dorsolateral prefrontal cortex. Two FDG-PET scans were done for all the patients. Fifty-six percent of patients responded to treatment with iTBS.

Results: We found that there was hypometabolism in left and right prefrontal lateral regions, left and right inferior parietal regions, and left prefrontal medial regions at baseline but no statistically significant difference in the metabolism between responders and nonresponders.

Conclusion: We did not find any statistically significant difference in the metabolism between responders and nonresponders in any brain regions at T0 as well as T1. Further large-scale studies are required.

Keywords: Depression; FDG PET; iTBS; neuroimaging; predictors; treatment resistance.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Graph of median Z-scores. Median Z-scores in different areas of the brain at baseline (T0) have been demonstrated before starting stimulation. Areas with Z-scores ≤ -2 were considered hypometabolic
Figure 2
Figure 2
Z-score map of a single patient. Red areas denote hypometabolism in prefrontal cortex. For details, refer Supplementary figures S1 and S2
See this image and copyright information in PMC

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