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. 2025 Jan-Mar;16(1):50-53.
doi: 10.4103/picr.picr_214_24. Epub 2024 Dec 26.

Novel trial designs: Master protocol trials

Priya Ranganathan  1 , Vishal Deo  2 , C S Pramesh  3 , Mahesh P Parmar  4
Affiliations

Novel trial designs: Master protocol trials

Priya Ranganathan et al. Perspect Clin Res. 2025 Jan-Mar.

Abstract

Conventional trial designs are resource and time-intensive. To accelerate the process of testing new interventions, we now have several novel research trial designs. This article focuses on master protocol trials, which allow several therapies to be tested within a single larger trial.

Keywords: Adaptive clinical trials as topic; clinical trials; research design.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Schematic representation of a basket trial
Figure 2
Figure 2
Schematic representation of an umbrella trial
Figure 3
Figure 3
Schematic representation of a platform trial
See this image and copyright information in PMC

References

    1. Ranganathan P, Aggarwal R. Study designs: Part 1 –An overview and classification. Perspect Clin Res. 2018;9:184–6. - PMC - PubMed
    1. Aggarwal R, Ranganathan P. Study designs: Part 2 –Descriptive studies. Perspect Clin Res. 2019;10:34–6. - PMC - PubMed
    1. Ranganathan P, Aggarwal R. Study designs: Part 3 –Analytical observational studies. Perspect Clin Res. 2019;10:91–4. - PMC - PubMed
    1. Aggarwal R, Ranganathan P. Study designs: Part 4 –Interventional studies. Perspect Clin Res. 2019;10:137–9. - PMC - PubMed
    1. Aggarwal R, Ranganathan P. Study designs: Part 5 –Interventional studies (II) Perspect Clin Res. 2019;10:183–6. - PMC - PubMed

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