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. 2025 Jan;41(1):257-262.
doi: 10.12669/pjms.41.1.8496.

Effect of Centratherum anthelminticum seeds on Glycated hemoglobin, Cardiovascular disease risks and dyslipidemia in Type-2 diabetic patients in Karachi: A non-blind randomized controlled trial

Hina Akram Mudassir  1 , Syed Muhammed Talha Arshad  2 , Munazzah Naheed  3 , Sadia Anwer  4
Affiliations

Effect of Centratherum anthelminticum seeds on Glycated hemoglobin, Cardiovascular disease risks and dyslipidemia in Type-2 diabetic patients in Karachi: A non-blind randomized controlled trial

Hina Akram Mudassir et al. Pak J Med Sci. 2025 Jan.

Abstract

Objective: To explore the effect of Centratherum antheminticum seeds powder {Cap CASP 500 mg} capsule in diabetes Type-2 (T2DM) patients in Karachi.

Methods: A randomized selection of 40 T2DM patients from Sindh Government Hospital New Karachi with their consents was done for a non-blinded controlled trial from October to December 2019 and divided into PGroup (Positive Control, metformin 500 mg) & TGroup (Test, Cap CASP + was also included, using the same dosage of CapCASP on twenty healthy volunteers. The data were analyzed using an online graph pad student's t-test and a one-way ANOVA (SPSS version 24) metformin 500mg each). Both groups had (n = 20). CGroup (healthy control), was also included with twenty healthy volunteers with same dose of Cap CASP. The biochemical tests (lipid profile, HbA1c, fasting blood glucose) of both groups were done in biochemistry lab Federal Urdu University of Arts, Science & Technology and results were analyzed by one-way ANOVA (SPSS version 24) and online graph pad student´s t-test.

Results: CASP showed potent (in-vitro) anti-diabetic activity (72.81%) than standard acarbose (standard drug). Most of in-vivo parameters in TGroup showed significant improvements. Body weight (p<0.01) & (p<0.05), HbA1c & fasting blood glucose (p<0.0001), coronary risk index (CRI), atherogenic index (A Indx) (p<0.05, p<0.0001) & atherogenic dyslipidemia ratio (A-DLR) (p<0.0001 & p<0.01) were reduced after six and twelve weeks. Reduction in serum cholesterol and triglycerides (p< 0.05 & p< 0.01) after six as well as (p< 0.01) after twelve weeks. Very low density lipoprotein reduced after both (p< 0.05) six and (p< 0.0001) twelve weeks. High density lipoprotein increased (p< 0.01) & low density lipoprotein decreased (p< 0.05) after twelve weeks.

Conclusion: When given standard care to T2D patients, the CASP intervention demonstrated both anti-diabetic and anti-lipidemic effects.

Keywords: Centratherum anthelminticum seeds; Diabetes; Fasting blood glucose; HbA1c.

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Conflict of interest statement

Conflict of Interest: None.

Figures

Fig.1
Fig.1
Study Design.
Fig.2
Fig.2
Effect of CapCASP on CRI, ADR & AI ratios in diabetic volunteers. All bars are mean ± SD n=20, dp< 0.05, ep< 0.01, and fp< 0.0001, when comparing with PGroup #p<0.05, * p<0.01 & +p<0.0001 when individual group compared with initial (1st day) record
See this image and copyright information in PMC

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