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. 2024 Dec 18;28(1):111607.
doi: 10.1016/j.isci.2024.111607. eCollection 2025 Jan 17.

Magnitude of cancer-associated thrombosis in Africa: A systematic review and meta-analysis

Astewle Andargie Baye  1 , Agimasie Tigabu  1 , Yirgalem Abere  1 , Birara Ayichew Tilaye  2 , Demewoz Kefale  2 , Lakachew Yismaw Bazezew  3 , Birhanu Mengist Munie  4 , Berihun Bantie  1 , Abebu Tegenaw Delie  5 , Dessalegn Haile  1
Affiliations

Magnitude of cancer-associated thrombosis in Africa: A systematic review and meta-analysis

Astewle Andargie Baye et al. iScience. .

Abstract

Comprehensive data on the epidemiology of cancer-related thrombosis in Africa has been sparse until recently. Thus, this review was aimed to investigate the magnitude of cancer-related thrombosis in Africa. To obtain key articles, comprehensive search was conducted using various databases. A random-effects model was used to determine the pooled magnitude. Heterogeneity across the studies was checked, and publication bias was determined. The pooled magnitude of thrombosis among cancer patients in Africa is 11.65% (95% confidence interval [CI]: 9.02-14.28). Advanced age, comorbidity, and level of D-dimer were the factors associated with cancer-associated thrombosis. Cancer-related thrombosis has become a significant public health burden in Africa. About 3 out of 25 cancer patients are at increased risk of acquiring thrombosis. It is better to provide training and capacity-building programs for healthcare providers in Africa on the prevention, diagnosis, and management of cancer-related thrombosis and develop standardized evidence-based multidisciplinary approach care guidelines.

Keywords: Cardiovascular medicine; Health sciences; Internal medicine; Medical specialty; Medicine; Oncology.

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Conflict of interest statement

The authors declare no competing interests. All authors assure that there are no financial and personal relationships with other people or organizations that could inappropriately influence (bias) our work.

Figures

None
Graphical abstract
Figure 1
Figure 1
Prisma flow diagram showing the steps for screening the articles to be included
Figure 2
Figure 2
Forest plot of the pooled magnitude of cancer-related thrombosis in Africa
Figure 3
Figure 3
Meta-funnel plot of the magnitude of cancer-related thrombosis among cancer patients in African region
Figure 4
Figure 4
Forest plot showing the association of age- and cancer-related thrombosis
Figure 5
Figure 5
Forest plot showing the association of comorbid conditions and cancer-related thrombosis
Figure 6
Figure 6
Forest plot showing the association of level of D-dimer and cancer-related thrombosis
See this image and copyright information in PMC

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