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. 2025 Jan 24;13(2):e9476.
doi: 10.1002/ccr3.9476. eCollection 2025 Feb.

Cutaneous involvement in multiple myeloma. A rare entity

L Rapparini  1   2 , A Pileri  1   2 , S Robuffo  1   2 , C Agostinelli  2   3 , Michelangelo La Placa  1   2
Affiliations

Cutaneous involvement in multiple myeloma. A rare entity

L Rapparini et al. Clin Case Rep. .

Abstract

Cutaneous involvement in multiple myeloma is rare and may present as nodules mimicking other lymphoid neoplasms. It typically occurs late in the course of the disease and is associated with an aggressive clinical course and poor prognosis.

Keywords: cutaneous; metastasis; multiple myeloma; secondarism.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
(A) Pink‐reddish nodules on the back. (B) Dermoscopy of the larger nodule showing superficial scales overlying a yellowish background.
FIGURE 2
FIGURE 2
(A) Dense infiltrate of neoplastic plasma cells throughout the dermis, sparing the epidermis (H&E 2×). (B) Higher magnification showing pleomorphism and high mitotic activity (H&E 10×). (C) Immunohistochemistry staining CD138 turned out to be positive (10×).
See this image and copyright information in PMC

References

    1. Rajkumar SV, Dimopoulos MA, Palumbo A, et al. International myeloma working group updated criteria for the diagnosis of multiple myeloma. Lancet Oncol. 2014;15:e538‐e548. - PubMed
    1. Panse G, Subtil A, McNiff JM, et al. Cutaneous involvement in plasma cell myeloma. Clinicopathological findings in a series of ten cases. Am J Clin Pathol. 2021;155:106‐116. - PubMed
    1. Bayer‐Garner IB, Smoller BR. The spectrum of cutaneous disease in multiple myeloma. J Am Acad Dermatol. 2003;48:497‐507. - PubMed

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