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Review
. 2025 Apr 1;25(2):115-122.
doi: 10.1097/ACI.0000000000001058. Epub 2025 Jan 27.

New approaches in childhood IgE-mediated food allergy treatment

Deniz Ilgun Gurel  1   2 , Aikaterini Anagnostou  3 , Alessandro Fiocchi  1 , Chinthrajah Sharon  4 , Umit Sahiner  2 , Sayantani Sindher  4 , Stefania Arasi  1
Affiliations
Review

New approaches in childhood IgE-mediated food allergy treatment

Deniz Ilgun Gurel et al. Curr Opin Allergy Clin Immunol. .

Abstract

Purpose of review: This review aims to provide an overview of the current and future treatment options for children with food allergies (FAs), highlighting the latest research findings and the potential impact of these new approaches on improving patients' and caregivers' quality of life.

Recent findings: In the last decade, many promising approaches have emerged as an alternative to the standard avoidance of the culprit food with the risk of severe accidental reactions. Desensitization through oral immunotherapy has been introduced in clinical settings as a therapeutic approach, and more recently also omalizumab. In addition, alternative routes of administration for immunotherapy, other biologics, small molecules, probiotics or prebiotics, microbiota transplantation therapy, IGNX001, and PVX108 are being investigated.

Summary: The portfolio of available treatment options for food allergies is increasing but several relevant unmet needs remain. This review aims to provide a brief overview of the existing and future treatment options for IgE-mediated food allergies.

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