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. 2025 Jun;80(6):1776-1781.
doi: 10.1111/all.16483. Epub 2025 Jan 27.

GWAS Identifies CACNA2D3 Associated With Asthma and Atopic Dermatitis Multimorbidity in Children

Dong Yun Kim  1   2 , Soyeon Lee  1 , Jae Hwa Jung  3 , Yujin Sub  1 , Sumin Lee  3 , Eun Gyul Kim  3 , Mi Na Kim  3 , Soo Yeon Kim  3 , Yoon Hee Kim  3 , Myung Hyun Sohn  3 , Heon Yung Gee  1 , Kyung Won Kim  3
Affiliations

GWAS Identifies CACNA2D3 Associated With Asthma and Atopic Dermatitis Multimorbidity in Children

Dong Yun Kim et al. Allergy. 2025 Jun.
No abstract available

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Genome‐wide association study (GWAS) reveals that CACNA2D3 is associated with childhood asthma and AD multimorbidity. (A) Manhattan plot of GWAS on persistent asthma and AD multimorbidity with allergic sensitization in Korean children. Variants are plotted on the x‐axis of the Manhattan plot according to their chromosomal position and their –log10 (p value) is shown on the y‐axis. The red line shows the genome‐wide significance threshold (p < 5 × 10−6). (B) Regional association plot at the CACNA2D3 locus for persistent childhood asthma and AD multimorbidity. The genome builds and linkage disequilibrium used in this plot is from hg19/1000 Genomes Asian (Nov 2014); the blue line indicates the recombination rate based on HapMap data. The 10 most significant SNPs in CACNA2D3 are labeled. Colors correspond to LD (r 2) with the lead SNP, rs78970585, as shown on the color scale in the upper right.
See this image and copyright information in PMC

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