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Review
. 2025;44(3):127-131.
doi: 10.1089/dna.2024.0283. Epub 2025 Jan 27.

The Emerging Role of Pleural Macrophages in Influenza Defense

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Review

The Emerging Role of Pleural Macrophages in Influenza Defense

Roksana Shirazi et al. DNA Cell Biol. 2025.

Abstract

The pleural cavity is gaining recognition as an important player in lung infections. Our recent research revealed that pleural macrophages (PMs) migrate from the pleural cavity into the lung during influenza virus infection, contributing to improved disease outcomes. This summary highlights key findings on the role of PMs in influencing viral lung infection outcomes and explores the potential directions for advancing this emerging field of study.

Keywords: influenza virus; lung infection; pleural cavity; pleural macrophages; serosal cavity.

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