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Case Reports
. 2025 Nov 1;44(6):561-566.
doi: 10.1097/PGP.0000000000001091. Epub 2025 Jan 9.

Testosterone-induced Seminal Vesicle-like Differentiation in Cervical Mesonephric Duct Remnants in a Female to Male Transgender Patient

Gayanie Ratnayake  1 , Karen L Talia  1 , Mila Volchek  1 , W Glenn McCluggage  2
Affiliations
Case Reports

Testosterone-induced Seminal Vesicle-like Differentiation in Cervical Mesonephric Duct Remnants in a Female to Male Transgender Patient

Gayanie Ratnayake et al. Int J Gynecol Pathol. .

Abstract

Pure ductal-type mesonephric remnants in the uterine cervix are rare. We report an unusual case in a 31-yr-old of cervical mesonephric remnants of predominantly ductal type exhibiting seminal vesicle-like differentiation in a female-to-male transgender patient receiving long-term testosterone therapy. To the best of our knowledge, this phenomenon has not been previously reported. The impact of testosterone on the female genital tract is likely to be encountered more frequently due to increasing rates of gender-affirming surgery, including long-term androgen use. Awareness of the morphologic features is important as such changes may be misinterpreted as premalignant or malignant lesions. In reporting this unusual case, we briefly review lesions derived from cervical mesonephric remnants and testosterone-associated changes in the female genital tract.

Keywords: Cervix; Mesonephric duct; Seminal vesicle; Testosterone; Transgender.

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Conflict of interest statement

The authors declare no conflict of interest.

References

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