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Review
. 2025 Jan 27;27(1):40.
doi: 10.1007/s11886-025-02195-x.

Contemporary Insights into LMNA Cardiomyopathy

Iswaree D Balakrishnan  1   2 , Neal K Lakdawala  3
Affiliations
Review

Contemporary Insights into LMNA Cardiomyopathy

Iswaree D Balakrishnan et al. Curr Cardiol Rep. .

Abstract

Purpose of review: This review aims to explore how a diagnosis of LMNA-related cardiomyopathy (LMNA-CM) informs clinical management, focusing on the prevention and management of its complications, through practical clinical strategies.

Recent findings: Longitudinal studies have enhanced our understanding of the natural history of LMNA-CM including its arrhythmic and non-arrhythmic complications. A LMNA specific ventricular arrhythmia risk prediction strategy has been integrated into clinical practice guidelines. Although less robust, observational studies are shaping gene-specific strategies for mitigating other complications including atrioventricular block, atrial fibrillation and cardiomyopathy, while novel therapies have been evaluated in clinical trials. LMNA-CM follows an aggressive yet generally stereotyped course. Early recognition of anticipated complications allows for more effective prevention and management in both symptomatic and asymptomatic patients.

Keywords: LMNA; Atrial fibrillation; Atrioventricular block; Genetic cardiomyopathy; Ventricular tachycardia.

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Conflict of interest statement

Declarations. Conflict of Interest: The authors declare no competing interests. Human and Animal Rights and Informed Consent: No animal or human subjects by the authors were used in this study.

References

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