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Review
. 2025 Jun;480(6):3455-3476.
doi: 10.1007/s11010-024-05169-9. Epub 2025 Jan 27.

Exploring ferroptosis and miRNAs: implications for cancer modulation and therapy

Mobarakeh Ajam-Hosseini  1 , Sadegh Babashah  2
Affiliations
Review

Exploring ferroptosis and miRNAs: implications for cancer modulation and therapy

Mobarakeh Ajam-Hosseini et al. Mol Cell Biochem. 2025 Jun.

Abstract

Ferroptosis is a novel, iron-dependent form of non-apoptotic cell death characterized by the accumulation of lipid reactive oxygen species (ROS) and mitochondrial shrinkage. It is closely associated with the onset and progression of various diseases, especially cancer, at all stages, making it a key focus of research for developing therapeutic strategies. Numerous studies have explored the role of microRNAs (miRNAs) in regulating ferroptosis by modulating the expression of critical genes involved in iron metabolism and lipid peroxidation. Due to their diversity, unique properties, and dynamic expression patterns in diseases, exosomal miRNAs are emerging as promising biomarkers. Exosomes act as biological messengers, delivering miRNAs to target cells through specific internalization, thus influencing the ferroptosis response in recipient cells. This review summarizes the roles of miRNAs, with particular focus on exosomal miRNAs, in ferroptosis and their implications for cancer pathology. By examining the molecular mechanisms of miRNAs, we aim to provide valuable insights into potential therapeutic approaches.

Keywords: Cancer therapy; Exosome; Ferroptosis; MiRNA; Molecular mechanism.

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Conflict of interest statement

Declarations. Conflict of interest: The authors declare no competing interests. Ethical approval: Not applicable. Consent for publication: Not applicable.

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