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. 2025 Feb;34(2):e70107.
doi: 10.1002/pds.70107.

Impact of Antibiotic Shortages on Antibiotic Utilisation in the Community

Maarten Lambert  1   2 , Katja Taxis  2 , Lisa Pont  1
Affiliations

Impact of Antibiotic Shortages on Antibiotic Utilisation in the Community

Maarten Lambert et al. Pharmacoepidemiol Drug Saf. 2025 Feb.

Abstract

Background: Drug shortages are an increasing and worldwide problem. Oral antibiotics are one of the most used medicines worldwide and have recently been affected by drug shortages. Despite this, little is known about the impact of antibiotic shortages on prescribing practices.

Aim: To explore the impact of oral antibiotic shortages on national antibiotic utilisation.

Methods: A cross-sectional study of oral antibiotic shortages and antibiotic utilisation was conducted using Australian reimbursement and regulatory data from January 2022 to December 2023. All nationally reimbursed oral antibiotics were included in the study. The number and duration of reported antibiotic shortages per product were determined for each active ingredient. The clinical impact was assessed using national utilisation in Defined Daily Doses per 100 000 inhabitants. Changes in trends were analysed using Joinpoint regression.

Results: Shortages were reported for eighteen of the twenty-one (86%) oral antibiotics reimbursed in Australia. For ten active ingredients, shortages did not coincide with changes in utilisation data. No clear relation between the number and duration of shortages and impact on utilisation was observed. Changes in utilisation coinciding with shortages were observed for eight active ingredients. For cefaclor (-20% decrease in utilisation) and roxithromycin (-26% decrease), the impact of shortages is most clearly reflected by decreases in utilisation. For the other six, minor changes in utilisation were observed coinciding with shortages.

Conclusions: Antibiotic shortages were common in Australia during 2022 and 2023. The impact of shortages differs per antibiotic, for some antibiotics there are shortages coinciding with declines in utilisation. For others, shortages occur without apparent changes in utilisation.

Keywords: antibiotics; community setting; drug shortages; drug utilisation; primary care.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Number and duration of shortages and antibiotic utilisation between January 2022 (Month 1) and December 2023 (Month 24).
FIGURE 2
FIGURE 2
Number and duration of shortages and antibiotic utilisation between January 2022 (Month 1) and December 2023 (Month 24). A grey bar indicates a product was not on the Australian market during that period.
FIGURE 3
FIGURE 3
Number and duration of shortages and antibiotic utilisation between January 2022 (Month 1) and December 2023 (Month 24). A grey bar indicates a product was not on the Australian market during that period.
FIGURE 4
FIGURE 4
Number and duration of shortages and antibiotic utilisation between January 2022 (Month 1) and December 2023 (Month 24). A grey bar indicates a product was not on the Australian market during that period.
FIGURE 5
FIGURE 5
Number and duration of shortages and antibiotic utilisation between January 2022 (Month 1) and December 2023 (Month 24). A grey bar indicates a product was not on the Australian market during that period.
FIGURE 6
FIGURE 6
Number and duration of shortages and antibiotic utilisation between January 2022 (Month 1) and December 2023 (Month 24). A grey bar indicates a product was not on the Australian market during that period.
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References

    1. Pharmaceutical Group of the European Union , Medicine Shortages PGEU Survey 2022 Results (Brussels: Pharmaceutical Group of the European Union (PGEU), 2023).
    1. Shafiq N., Pandey A. K., Malhotra S., et al., “Shortage of Essential Antimicrobials: A Major Challenge to Global Health Security,” BMJ Global Health 6, no. 11 (2021): 6961, 10.1136/BMJGH-2021-006961. - DOI - PMC - PubMed
    1. Shukar S., Zahoor F., Hayat K., et al., “Drug Shortage: Causes, Impact, and Mitigation Strategies,” Frontiers in Pharmacology 12 (2021): 693426, 10.3389/fphar.2021.693426. - DOI - PMC - PubMed
    1. Miljković N., Polidori P., and Kohl S., “Managing Antibiotic Shortages: Lessons From EAHP and ECDC Surveys,” European Journal of Hospital Pharmacy 29, no. 2 (2022): 90–94, 10.1136/ejhpharm-2021-003110. - DOI - PMC - PubMed
    1. Access to Medicine Foundation , Cogan D., Karrar K., et al., Shortages, Stockouts and Scarcity. The Issues Facing the Security of Antibiotic Supply and the Role for Pharmaceutical Companies (Amsterdam: Access to Medicine Foundation, 2018).

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