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Editorial
. 2025 Apr;48(4):1631-1633.
doi: 10.1038/s41440-024-02094-8. Epub 2025 Jan 27.

Significance and perspective of establishing a female animal model for heart failure with preserved ejection fraction

Shungo Hikoso  1
Affiliations
Editorial

Significance and perspective of establishing a female animal model for heart failure with preserved ejection fraction

Shungo Hikoso. Hypertens Res. 2025 Apr.
No abstract available

Keywords: HFpEF; animal model; sex difference.

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Conflict of interest statement

Compliance with ethical standards. Conflict of interest: The author declares no competing interests.

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References

    1. Nagai T, Yoshikawa T, Saito Y, Takeishi Y, Yamamoto K, Ogawa H, et al. Clinical Characteristics, Management, and Outcomes of Japanese Patients Hospitalized for Heart Failure With Preserved Ejection Fraction- A Report From the Japanese Heart Failure Syndrome With Preserved Ejection Fraction (JASPER) Registry. Circulation J : Off J Jpn Circulation Soc. 2018;82:1534–45. https://doi.org/10.1253/circj.CJ-18-0073 . - DOI
    1. Sotomi Y, Hikoso S, Nakatani D, Mizuno H, Okada K, Dohi T, et al. Sex Differences in Heart Failure With Preserved Ejection Fraction. J Am Heart Assoc. 2021;10:e018574. https://doi.org/10.1161/JAHA.120.018574 . - DOI - PubMed - PMC
    1. Merrill M, Sweitzer NK, Lindenfeld J, Kao DP. Sex Differences in Outcomes and Responses to Spironolactone in Heart Failure With Preserved Ejection Fraction: A Secondary Analysis of TOPCAT Trial. JACC Heart Fail. 2019;7:228–38. https://doi.org/10.1016/j.jchf.2019.01.003 . - DOI - PubMed - PMC
    1. McMurray JJV, Jackson AM, Lam CSP, Redfield MM, Anand IS, Ge J, et al. Effects of Sacubitril-Valsartan Versus Valsartan in Women Compared With Men With Heart Failure and Preserved Ejection Fraction: Insights From PARAGON-HF. Circulation. 2020;141:338–51. https://doi.org/10.1161/circulationaha.119.044491 . - DOI - PubMed
    1. Jasińska-Stroschein M. Searching for an experimental rodent model of heart failure with preserved ejection fraction: Re-visited. Biomedicine Pharmacother = Biomedecine pharmacotherapie. 2022;152:113251. https://doi.org/10.1016/j.biopha.2022.113251 . - DOI

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