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Editorial
. 2025 Apr;48(4):1636-1638.
doi: 10.1038/s41440-025-02115-0. Epub 2025 Jan 28.

Impact of SARS-CoV-2 variants on viral infectivity and the role of the renin-angiotensin-aldosterone system

Yasushi Matsuzawa  1 , Kenichi Tsujita  2
Affiliations
Editorial

Impact of SARS-CoV-2 variants on viral infectivity and the role of the renin-angiotensin-aldosterone system

Yasushi Matsuzawa et al. Hypertens Res. 2025 Apr.

Abstract

Balance between Protective vs. Exacerbating Effects of ACEIs and ARBs in Omicron Variant Infections. The spike protein on the surface of the Omicron variant has a high affinity for ACE2, making it more prone to enter cells and induce ACE2 downregulation. Therefore, the effects of ACEIs and ARBs on Omicron variant infections may differ from those of the previous variants. The current study demonstrates that ACEIs and ARBs do not aggravate or prolong COVID-19 due to Omicron variant infections.

Keywords: COVID-19; Omicron; RAAS inhibitor.

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Conflict of interest statement

Compliance with ethical standards. Conflict of interest: The authors declare no competing interests.

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References

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