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Observational Study
. 2025 Jan 27;25(1):124.
doi: 10.1186/s12879-025-10453-0.

A serosurvey study of hand, foot and mouth disease in healthy children aged 6 to 71 months old in West Bandung and Bandung Region, Indonesia

Rodman Tarigan Girsang  1 , Kusnandi Rusmil  2 , Eddy Fadlyana  2 , Budi Setiabudiawan  2   3 , Riyadi Adrizain  2 , Rizky Perdana Mulyadi  2 , Arief Budiman  2 , Rona Kania Utami  2 , Behesti Zahra Mardiah  2 , Muhammad Gilang Dwi Putra  2 , Frizka Primadewi Fulendry  2 , Dinda Tiaraningrum Nashsyah  2 , Hadyana Sukandar  4
Affiliations
Observational Study

A serosurvey study of hand, foot and mouth disease in healthy children aged 6 to 71 months old in West Bandung and Bandung Region, Indonesia

Rodman Tarigan Girsang et al. BMC Infect Dis. .

Abstract

Background: Hand, foot, and mouth disease (HFMD) is an infectious disease that often affects children under 5 years of age. Over the past 20 years, enterovirus 71 (EV71) has become a major concern among children, especially in the Asia-Pacific region. Currently, there are no data showing the seroprevalence of HMFDs in Indonesia. This study aimed to determine the seroprevalence of antibodies to EV71 infection in rural and urban areas.

Methods: This study was an observational analysis and cross-sectional seroprevalence survey of HFMD in children aged 6 to 71 months. The sampling locations were the Padalarang health centre, which is rural, and the Garuda health centre, which is urban. The total sample included 600 children aged 6-71 months from these two locations. Blood sample testing uses enzyme-linked immunosorbent assays (ELISAs) to identify subjects who are positive for IgG EV71 and the risk factors that may influence it.

Results: In total, 596 subjects (99.3%) were positive for the seroprevalence of EV71 IgG in rural and urban areas. Child age, sex, nutritional status, height/age, immunisation status, parental income, and father's and mother's educations were not statistically related in rural and urban areas (p > 0.05) because the rate of IgG EV71 seropositivity was very high.

Conclusion: This study revealed that the rate of IgG EV71 HFMD seropositivity in Indonesia, especially in the Padalarang health centre and Garuda health centre, was very high. Further research is needed to investigate HFMD cases because of the lack of attention given to this disease and the need to consider whether immunisation is necessary to prevent HFMD.

Trial registration: This study is registered at clinicaltrials.gov, National Clinical Trial (NCT) No. NCT05637229.

Keywords: EV71; Foot and mouth disease; Hand; Serosurvey.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: This study was approved by The Research Ethics Committee, Padjadjaran University, Indonesia (ethical approval No. 100/UN6. KEP/EC/2022), which is registered at clinicaltrials.gov, National Clinical Trial (NCT) No. NCT05637229 05/12/2022. The investigator will be responsible for obtaining approval of the protocol from the Institutional Ethics Committee before starting the trial and approving all amendments in compliance with local law. After being informed about the nature of the study, written informed consent was obtained from the parents or guardians of the subjects. Consent for publication: All of the participants signed a written informed consent agreement to publish their data for this research. Competing interests: The authors declare no competing interests.

Figures

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Fig. 1
Participant flowchart
See this image and copyright information in PMC

References

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