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. 2025 Apr;40(4):940-948.
doi: 10.1111/jgh.16883. Epub 2025 Jan 27.

Artificial Liver Support System Improves One-Year Prognosis of Patients With Hepatitis B Virus-Associated Acute-on-Chronic Liver Failure

Xiaoqin Lan  1 , Changze Hong  1 , Xiaofeng Zhang  1   2 , Ling Zhou  1 , Yuan Li  1 , Caili Zhang  1 , Xingyan Mo  1 , Jing Zhou  1 , Beiling Li  1 , Tingting Qi  1 , Qinjun He  1 , Wenfan Luo  1 , Qintao Lai  1 , Yali Ji  1 , Ying Xu  1 , Junwei Liu  1 , Fuyuan Zhou  1 , Jinjun Chen  1   2   3
Affiliations

Artificial Liver Support System Improves One-Year Prognosis of Patients With Hepatitis B Virus-Associated Acute-on-Chronic Liver Failure

Xiaoqin Lan et al. J Gastroenterol Hepatol. 2025 Apr.

Abstract

Background & aims: Acute-on-chronic liver failure (ACLF) is a complex syndrome with limited treatment options. This study aims to investigate the impact of artificial liver support system (ALSS) on the one-year prognosis of patients with Hepatitis B virus (HBV)-associated ACLF.

Method: A retrospective study was conducted on 239 patients with HBV-ACLF in Nanfang Hospital from January 2016 to June 2021. Patients were divided into the ALSS group (n = 103) and the Standard Medical Therapy (SMT group, n = 136). Demographic, clinical, and laboratory data were collected before the first ALSS treatment for patients in ALSS group, while baseline data were collected in SMT group. According to receiving different ALSS modes, patients in ALSS group were divided into plasma exchange (PE) group and non-PE group.

Result: The 12-week and 1-year liver transplant (LT) free survival rates in the ALSS group were significantly higher than that in the SMT group (65.05% vs 52.21%, p = 0.0011; 63.11% vs. 48.53%, p = 0.0006). ALSS therapy was the independent predictive factors associated with 12-week and 1-year mortality (hazard ratio, HR: 0.59, p = 0.04, and HR: 0.54, p = 0.01). Comparatively more ALSS-related complications were observed in PE group. After Propensity Score Matching, the 12-week and 1-year LT-free survival rates between PE and non-PE group were similar (88% vs. 80%, p = 0.227, 88% vs. 80%, p = 0.227).

Conclusion: ALSS therapy is a safe and effective treatment for HBV-ACLF. ALSS improves 1-year prognosis of patients with HBV-ACLF.

Keywords: double plasma molecular adsorption system; liver failure; one‐year mortality; plasma exchange; short‐term mortality.

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References

    1. R. Moreau, R. Jalan, P. Gines, et al., “Acute‐On‐Chronic Liver Failure Is a Distinct Syndrome That Develops in Patients With Acute Decompensation of Cirrhosis,” Gastroenterology 144, no. 7 (2013): 1426–1437, 1437.e1–9, https://doi.org/10.1053/j.gastro.2013.02.042 Epub 2013 Mar 6. PMID: 23474284, 1437.e9.
    1. T. Wu, J. Li, L. Shao, et al., “Chinese Group on the Study of Severe Hepatitis B (COSSH). Development of Diagnostic Criteria and a Prognostic Score for Hepatitis B Virus‐Related Acute‐On‐Chronic Liver Failure,” Gut 67, no. 12 (2018): 2181–2191, https://doi.org/10.1136/gutjnl‐2017‐314641 Epub 2017 Sep 19. PMID: 28928275.
    1. L. S. Belli, C. Duvoux, T. Artzner, et al., “Liver Transplantation for Patients With Acute‐On‐Chronic Liver Failure (ACLF) in Europe: Results of the ELITA/EF‐CLIF Collaborative Study (ECLIS),” Journal of Hepatology 75, no. 3 (2021): 610–622, https://doi.org/10.1016/j.jhep.2021.03.030 Epub 2021 May 2. PMID: 33951535.
    1. L. J. Li, Y. M. Zhang, X. L. Liu, et al., “Artificial Liver Support System in China: A Review Over the Last 30 Years,” Therapeutic Apheresis and Dialysis 10 (2006): 160–167.
    1. G. Qin, J.‐G. Shao, B. Wang, et al., “Artificial Liver Support System Improves Short and Long‐Term Outcomes of Patients With HBV‐Associated Acute‐On‐Chronic Liver Failure: A Single‐Center Experience,” Medicine 93 (2014): e338.

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