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Review
. 2025 Jan;48(1):e70087.
doi: 10.1002/clc.70087.

Advancements in Artificial Intelligence in Noninvasive Cardiac Imaging: A Comprehensive Review

Oluwaremilekun Zeth Tolu-Akinnawo  1 , Francis Ezekwueme  2 , Olukunle Omolayo  3 , Sasha Batheja  4 , Toluwalase Awoyemi  5
Affiliations
Review

Advancements in Artificial Intelligence in Noninvasive Cardiac Imaging: A Comprehensive Review

Oluwaremilekun Zeth Tolu-Akinnawo et al. Clin Cardiol. 2025 Jan.

Abstract

Background: Technological advancements in artificial intelligence (AI) are redefining cardiac imaging by providing advanced tools for analyzing complex health data. AI is increasingly applied across various imaging modalities, including echocardiography, magnetic resonance imaging (MRI), computed tomography (CT), and nuclear imaging, to enhance diagnostic workflows and improve patient outcomes.

Hypothesis: Integrating AI into cardiac imaging enhances image quality, accelerates processing times, and improves diagnostic accuracy, enabling timely and personalized interventions that lead to better health outcomes.

Methods: A comprehensive literature review was conducted to examine the impact of machine learning and deep learning algorithms on diagnostic accuracy, the detection of subtle patterns and anomalies, and key challenges such as data quality, patient safety, and regulatory barriers.

Results: Findings indicate that AI integration in cardiac imaging enhances image quality, reduces processing times, and improves diagnostic precision, contributing to better clinical decision-making. Emerging machine learning techniques demonstrate the ability to identify subtle cardiac abnormalities that traditional methods may overlook. However, significant challenges persist, including data standardization, regulatory compliance, and patient safety concerns.

Conclusions: AI holds transformative potential in cardiac imaging, significantly advancing diagnosis and patient outcomes. Overcoming barriers to implementation will require ongoing collaboration among clinicians, researchers, and regulatory bodies. Further research is essential to ensure the safe, ethical, and effective integration of AI in cardiology, supporting its broader application to improve cardiovascular health.

Keywords: AI (artificial intelligence); cardiac imaging techniques; health care reforms; precision medicine.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
The figure illustrates AI application in noninvasive cardiac imaging. Source: Francis Ezekwueme: one of the authors.
See this image and copyright information in PMC

References

    1. Alowais S. A., Alghamdi S. S., Alsuhebany N., et al., “Revolutionizing Healthcare: The Role of Artificial Intelligence in Clinical Practice,” BMC Medical Education 23, no. 1 (2023): 689, 10.1186/s12909-023-04698-z. - DOI - PMC - PubMed
    1. Bohr A. and Memarzadeh K., “The Rise of Artificial Intelligence in Healthcare Applications,” Artificial Intelligence in Healthcare, (2020): 25–60, 10.1016/b978-0-12-818438-7.00002-2. - DOI
    1. Willemink M. J., Varga‐Szemes A., Schoepf U. J., et al., “Emerging Methods for the Characterization of Ischemic Heart Disease: Ultrafast Doppler Angiography, Micro‐CT, Photon‐Counting CT, Novel MRI and PET Techniques, and Artificial Intelligence,” European Radiology Experimental 5, no. 1 (2021): 12, 10.1186/s41747-021-00207-3. - DOI - PMC - PubMed
    1. Sachdeva P., Kaur K., Fatima S., et al., “Advancements in Myocardial Infarction Management: Exploring Novel Approaches and Strategies,” Cureus 15, no. 9 (2023): 45578, 10.7759/cureus.45578. - DOI - PMC - PubMed
    1. Peterson P. G., Berge M., J. P. Lichtenberger, 3rd , Hood M. N., and Ho V. B., “Cardiac Imaging Modalities and Appropriate Use,” Primary Care: Clinics in Office Practice 45, no. 1 (2018): 155–168, 10.1016/j.pop.2017.10.006. - DOI - PubMed

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