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Review
. 2025 Mar;110(3):370-381.
doi: 10.1113/EP091813. Epub 2025 Jan 27.

Physiology of bridging stent grafts after fenestrated/branched endovascular aortic repair: Where translational science meets the clinical profile

Thurkga Moothathamby  1 , Matti Jubouri  2 , Tharun Rajasekar  3 , Subham Roy  2 , Maya Alfwaress  4 , Samuel S S Rezk  5 , Samuel N S Ghattas  5 , Mario D'Oria  6 , Damian M Bailey  7 , Ian M Williams  8 , Mohamad Bashir  7
Affiliations
Review

Physiology of bridging stent grafts after fenestrated/branched endovascular aortic repair: Where translational science meets the clinical profile

Thurkga Moothathamby et al. Exp Physiol. 2025 Mar.

Abstract

Fenestrated/branched endovascular aortic repair emerges as the primary therapeutic modality for intricate aortic pathologies encompassing the paravisceral and thoracoabdominal segments, where bridging stent grafts (BSGs) play a vital role in linking the primary aortic endograft with target vessels. Bridging stent grafts can be categorized mainly into self-expanding stent grafts (SESGs) and balloon-expandable stent grafts (BESGs). Physiological factors significantly influence post-complex endovascular aortic repair BSG behaviour, impacting clinical outcomes of SESGs and BESGs in different but overlapping ways. Crucial prerequisites for BSGs encompass not only flexibility but also resilience against mechanical stress and compliance mismatch, especially when bridging the rigid aortic main body with dynamic target vessels. The significance of considering these physiological factors in clinical decision-making is underscored by recognizing the interplay between SESG and BESG characteristics, vessel physiology and patient haemorheology. Such factors include the anatomy and tortuosity of the vessel, diameter of the vessel and BSG, deployment and durability, extrinsic stenosis and respiratory motion. Haemorheological factors, such as anti-thrombotic therapy and hydration status, need to be considered. This narrative review examines both in vitro and in vivo evidence regarding the impact of physiological factors on the behaviour of BSGs and assesses the consequences for clinical outcomes following complex endovascular aortic repair.

Keywords: balloon‐expandable; branched; bridging stent graft; complex endovascular aortic repair endovascular aortic repair; endovascular aortic repair; fenestrated; haemorheology; self‐expanding; vessel physiology.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Visual illustration of fenestrated (left) and branched (right) endovascular aortic repair. Re‐used from Oderich et al. (2017), with permission.
See this image and copyright information in PMC

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