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. 2023 Nov 27;3(1):load046.
doi: 10.1093/lifemeta/load046. eCollection 2024 Feb.

A metabolic signalling role for arginine in liver cancer

David Sokolov  1 , Lucas B Sullivan  1
Affiliations

A metabolic signalling role for arginine in liver cancer

David Sokolov et al. Life Metab. .
No abstract available

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Conflict of interest statement

The authors declare that no conflict of interest exists.

Figures

Figure 1
Figure 1
Arginine as an oncogenic signalling molecule in HCC. In non-tumour tissue (left panel), arginine is primarily synthesized de novo via the urea cycle, and intracellular arginine levels are kept low by ARG1/AGMAT. Mossmann et al. show that in models of HCC (right panel), de novo arginine synthesis is downregulated, and cells instead scavenge environmental arginine through SLC family transporters. ARG1/AGMAT levels are also reduced, and accumulated arginine is bound by RBM39, which enacts transcriptional changes promoting tumourigenesis. Created with BioRender.com.
See this image and copyright information in PMC

References

    1. Mossmann D, Müller C, Park Set al. Cell 2023;186:5068–83.e23. - PMC - PubMed
    1. Saxton RA, Chantranupong L, Knockenhauer KEet al. Nature 2016;536:229–33. - PMC - PubMed
    1. Qiu F, Huang J, Sui M.. Cancer Lett 2015;364:1–7. - PubMed
    1. Hajaj E, Sciacovelli M, Frezza Cet al. Mol Cell 2021;81:3749–59. - PubMed
    1. Missiaen R, Anderson NM, Kim LCet al. Cell Metab 2022;34:1151–67.e7. - PMC - PubMed

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