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. 2025 Jan 27;17(1):101619.
doi: 10.4254/wjh.v17.i1.101619.

Timing of post-vaccination tests in infants born to mothers with chronic hepatitis B virus infection

Halil Haldun Emiroglu  1 , Melike Emiroglu  2
Affiliations

Timing of post-vaccination tests in infants born to mothers with chronic hepatitis B virus infection

Halil Haldun Emiroglu et al. World J Hepatol. .

Abstract

Immunoprophylaxis is routinely recommended for infants born to mothers with hepatitis B virus (HBV) infection within the first 12-24 hours. Detection of hepatitis B surface antibody (HBsAb) resulting from hepatitis B immunoglobulin administered at birth may be perceived as a real vaccine response. This makes it difficult to detect HBV infection. For this reason, it is recommended that infants born to hepatitis B surface antigen positive mothers and who received immunoprophylaxis at birth should have HBsAb testing when they are 9-15 months old.

Keywords: Hepatitis B hyperimmune globulin; Hepatitis B vaccine; Hepatitis B virus; Infant; Vaccination.

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Conflict of interest statement

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

References

    1. Darar Dirir S, Ahouidi AD, Drame A, Osman Abdi W, Youssouf Kayad G, Houmed Aboubakar M, Camara M, Toure Kane C, Diop Ndiaye H. Immunoprophylaxis failure and vaccine response in infants born to mothers with chronic hepatitis B infection in Djibouti. World J Hepatol. 2024;16:1039–1050. - PMC - PubMed
    1. Terrault NA, Lok ASF, McMahon BJ, Chang KM, Hwang JP, Jonas MM, Brown RS Jr, Bzowej NH, Wong JB. Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance. Hepatology. 2018;67:1560–1599. - PMC - PubMed
    1. Schillie S, Vellozzi C, Reingold A, Harris A, Haber P, Ward JW, Nelson NP. Prevention of Hepatitis B Virus Infection in the United States: Recommendations of the Advisory Committee on Immunization Practices. MMWR Recomm Rep. 2018;67:1–31. - PMC - PubMed

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